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• W1988388575 startingPage "217" @default.
• W1988388575 abstract "The biophysical and pharmacological properties of the inwardly rectifying Cl− conductance (IClh), expressed in rat type-1 neocortical cultured astrocytes upon a long-term treatment (1–3 weeks) with dibutyryl-cyclic-AMP (dBcAMP), were investigated with the whole-cell patch-clamp technique. Using intra- and extra-cellular solutions with symmetrical high Cl− content and with the monovalent cations replaced with N-methyl-D-glucamine, time- and voltage-dependent Cl− currents were elicited in response to hyperpolarizing voltage steps from a holding potential of 0 mV. The inward currents activated slowly and did not display any time-dependent inactivation. The rising phase of the current traces was best fitted with two exponential components whose time constants decreased with larger hyperpolarization. The steady-state activation of IClh was well described by a single Boltzmann function with a half-maximal activation potential at −62 mV and a slope of 19 mV that yields to an apparent gating charge of 1.3. The anion selectivity sequence was Cl− = Br− = I− > F− > cyclamate ≥ gluconate. External application of the putative Cl− channel blockers 4,4 diisothiocyanatostilbene-2,2 disulphonic acid or 4-acetamido-4-isothiocyanatostilbene-2,2-disulphonic acid did not affect IClh. By contrast, anthracene-9-carboxylic acid, as well as Cd2+ and Zn2+, inhibited, albeit with different potencies, the Cl− current. Taken together, these results indicate that dBcAMP-treated cultured rat cortical astrocytes express a Cl− inward rectifier, which exhibits similar but not identical features compared with those of the cloned and heterologously expressed hyperpolarization-activated Cl− channel ClC-2. GLIA 21:217–227, 1997. © 1997 Wiley-Liss, Inc." @default.
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• W1988388575 date "1997-10-01" @default.
• W1988388575 modified "2023-09-26" @default.
• W1988388575 title "Characterization of an inwardly rectifying chloride conductance expressed by cultured rat cortical astrocytes" @default.
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• W1988388575 doi "https://doi.org/10.1002/(sici)1098-1136(199710)21:2<217::aid-glia5>3.0.co;2-3" @default.
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