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• W1988405378 abstract "You have accessJournal of UrologyProstate Cancer: Localized1 Apr 20111477 ACTIVE SURVEILLANCE – CAN WE REDUCE THE RATE OF FAILURE? Samarth Chopra, David Tamblyn, Tina Kopsaftis, and Carole Pinnock Samarth ChopraSamarth Chopra Adelaide, Australia More articles by this author , David TamblynDavid Tamblyn Adelaide, Australia More articles by this author , Tina KopsaftisTina Kopsaftis Adelaide, Australia More articles by this author , and Carole PinnockCarole Pinnock Adelaide, Australia More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1412AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Active Surveillance (AS) is now a widely recognised management option for newly diagnosed low risk prostate cancer patients meeting specific criteria. We investigated failure to predict poor pathological and recurrence outcomes, and further developed four published AS criteria in a SA patient cohort. METHODS We studied prospectively collected data on 579 patients undergoing radical prostatectomy for localised prostate cancer (CaP) at three public hospitals in South Australia between 1998–2009. Patients meeting the Hardie, Roemeling, Choo and D'Amico criteria (Suardi et al Cancer 2008; 112: 2068) were compared for surgical pathology and biochemical recurrence-free survival. RESULTS Patients had mean age 62 [range 37–80] years, mean PSA at biopsy 8.6 ng/ml. Considered by the 4 criteria sets, 27–37% had extra-capsular extension, 3–6% seminal vesicle invasion, 1–3% Gleason 8+ and 6–9% recurred at three years with 30-62% patients having at least one unfavourable outcome. Addition of tumour size at diagnosis (percent positive biopsies or PPB<=25%) improved performance with only 21-28% patients having an unfavourable pathology outcome and no recurrences at five years for D'Amico criteria (see Figure). CONCLUSIONS D'Amico criteria plus PPB may predict suitability for AS with a low failure rate. Our findings are useful for both patients and clinicians who deal with complex treatment decisions. The level of misclassification for this combination (no recurrences at 5 years) is probably better than most criteria combinations in the literature. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e592 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Samarth Chopra Adelaide, Australia More articles by this author David Tamblyn Adelaide, Australia More articles by this author Tina Kopsaftis Adelaide, Australia More articles by this author Carole Pinnock Adelaide, Australia More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W1988405378 title "1477 ACTIVE SURVEILLANCE – CAN WE REDUCE THE RATE OF FAILURE?" @default.
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