Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988406500> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1988406500 endingPage "448" @default.
- W1988406500 startingPage "431" @default.
- W1988406500 abstract "1. At concentrations of 2·8 × 10−8-2·8 × 10−6 M, prostaglandins (PGs; PGE1, PGE2 and PGF2α) had no effect on membrane potential and resistance of smooth muscles of the guinea-pig mesenteric artery. PGs (2·8 × 10−8 M) suppressed the contraction evoked by perivascular nerve stimulation, but did not suppress the contraction evoked by direct muscle stimulation. 2. PGs (2·8 × 10−8 M) suppressed the e.j.p.s evoked by repetitive perivascular nerve stimulation but preserved the facilitation process of e.j.p.s evoked by any given stimulus frequency (0·1-1·0 Hz). 3. The relationships between e.j.p. amplitudes and [Ca]o plotted on log scales in the presence or absence of PGE2 were not parallel. High concentrations of [Ca]o prevented the inhibitory actions of PGs on the amplitude of e.j.p.s. 4. PGE2 did not suppress the activity of nerve fibres contributing to the generation of e.j.p. 5. Indomethacin (10−6 M) enhanced the amplitude of e.j.p.s and the frequency of miniature e.j.p.s with no change in the membrane potential and resistance of smooth muscles; these actions of indomethacin were suppressed by PGE2 (2·8 × 10−8 M). 6. Phentolamine (10−7 M) enlarged and yohimbine (10−7 M) reduced the amplitude of the first e.j.p. evoked by a train stimulation, but the maximum amplitude of e.j.p., after the facilitation was completed, was in both cases much larger than that observed in the control. The enhancement of the transmission process was also suppressed by PGs (2·8 × 10−8 M). 7. The results indicate that in the guinea-pig mesenteric artery, PGs mainly suppress chemical transmitter release from nerve terminals due to interactions with Ca influx, but not due to interaction with presynaptic α-adrenoceptors. Endogenous PG may act as a regulator substance in neuromuscular transmission." @default.
- W1988406500 created "2016-06-24" @default.
- W1988406500 creator A5036355904 @default.
- W1988406500 creator A5081156883 @default.
- W1988406500 date "1982-06-01" @default.
- W1988406500 modified "2023-10-15" @default.
- W1988406500 title "Modulation of neuromuscular transmission by endogenous and exogenous prostaglandins in the guinea-pig mesenteric artery" @default.
- W1988406500 cites W1966754120 @default.
- W1988406500 cites W1973866585 @default.
- W1988406500 cites W1982145754 @default.
- W1988406500 cites W2003629634 @default.
- W1988406500 cites W2008632370 @default.
- W1988406500 cites W2017367839 @default.
- W1988406500 cites W2026148927 @default.
- W1988406500 cites W2038186705 @default.
- W1988406500 cites W2044017530 @default.
- W1988406500 cites W2064976294 @default.
- W1988406500 cites W2070716170 @default.
- W1988406500 cites W2081377274 @default.
- W1988406500 cites W2084622003 @default.
- W1988406500 cites W2125841904 @default.
- W1988406500 cites W2127266930 @default.
- W1988406500 cites W2150751984 @default.
- W1988406500 cites W2153175570 @default.
- W1988406500 cites W2158216295 @default.
- W1988406500 cites W2318396751 @default.
- W1988406500 cites W2318711613 @default.
- W1988406500 doi "https://doi.org/10.1113/jphysiol.1982.sp014241" @default.
- W1988406500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1225118" @default.
- W1988406500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6288928" @default.
- W1988406500 hasPublicationYear "1982" @default.
- W1988406500 type Work @default.
- W1988406500 sameAs 1988406500 @default.
- W1988406500 citedByCount "34" @default.
- W1988406500 crossrefType "journal-article" @default.
- W1988406500 hasAuthorship W1988406500A5036355904 @default.
- W1988406500 hasAuthorship W1988406500A5081156883 @default.
- W1988406500 hasBestOaLocation W19884065001 @default.
- W1988406500 hasConcept C105702510 @default.
- W1988406500 hasConcept C126322002 @default.
- W1988406500 hasConcept C134018914 @default.
- W1988406500 hasConcept C15744967 @default.
- W1988406500 hasConcept C163415756 @default.
- W1988406500 hasConcept C17077164 @default.
- W1988406500 hasConcept C185592680 @default.
- W1988406500 hasConcept C24998067 @default.
- W1988406500 hasConcept C2776050358 @default.
- W1988406500 hasConcept C2778815084 @default.
- W1988406500 hasConcept C2779918689 @default.
- W1988406500 hasConcept C2780253649 @default.
- W1988406500 hasConcept C3020341438 @default.
- W1988406500 hasConcept C542102704 @default.
- W1988406500 hasConcept C71924100 @default.
- W1988406500 hasConcept C86803240 @default.
- W1988406500 hasConceptScore W1988406500C105702510 @default.
- W1988406500 hasConceptScore W1988406500C126322002 @default.
- W1988406500 hasConceptScore W1988406500C134018914 @default.
- W1988406500 hasConceptScore W1988406500C15744967 @default.
- W1988406500 hasConceptScore W1988406500C163415756 @default.
- W1988406500 hasConceptScore W1988406500C17077164 @default.
- W1988406500 hasConceptScore W1988406500C185592680 @default.
- W1988406500 hasConceptScore W1988406500C24998067 @default.
- W1988406500 hasConceptScore W1988406500C2776050358 @default.
- W1988406500 hasConceptScore W1988406500C2778815084 @default.
- W1988406500 hasConceptScore W1988406500C2779918689 @default.
- W1988406500 hasConceptScore W1988406500C2780253649 @default.
- W1988406500 hasConceptScore W1988406500C3020341438 @default.
- W1988406500 hasConceptScore W1988406500C542102704 @default.
- W1988406500 hasConceptScore W1988406500C71924100 @default.
- W1988406500 hasConceptScore W1988406500C86803240 @default.
- W1988406500 hasIssue "1" @default.
- W1988406500 hasLocation W19884065001 @default.
- W1988406500 hasLocation W19884065002 @default.
- W1988406500 hasLocation W19884065003 @default.
- W1988406500 hasOpenAccess W1988406500 @default.
- W1988406500 hasPrimaryLocation W19884065001 @default.
- W1988406500 hasRelatedWork W2023143250 @default.
- W1988406500 hasRelatedWork W2038939400 @default.
- W1988406500 hasRelatedWork W2070101498 @default.
- W1988406500 hasRelatedWork W2355154560 @default.
- W1988406500 hasRelatedWork W2362448193 @default.
- W1988406500 hasRelatedWork W2393800486 @default.
- W1988406500 hasRelatedWork W2414160678 @default.
- W1988406500 hasRelatedWork W3099234894 @default.
- W1988406500 hasRelatedWork W2437573122 @default.
- W1988406500 hasRelatedWork W3143305693 @default.
- W1988406500 hasVolume "327" @default.
- W1988406500 isParatext "false" @default.
- W1988406500 isRetracted "false" @default.
- W1988406500 magId "1988406500" @default.
- W1988406500 workType "article" @default.