FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988412071> ?p ?o ?g. }

• W1988412071 endingPage "16300" @default.
• W1988412071 startingPage "16293" @default.
• W1988412071 abstract "The origins of differentiation of insulin from insulin-like growth factor I (IGF-I) are still unknown. To address the problem of a structural and biological switch from the mostly metabolic hormonal activity of insulin to the predominant growth factor activities of IGF-I, an insulin analogue with IGF-I-like structural features has been synthesized. Insulin residues PheB25 and TyrB26 have been swapped with the IGF-I-like Tyr24 and Phe25 sequence with a simultaneous methylation of the peptide nitrogen of residue PheB26. These modifications were expected to introduce a substantial kink in the main chain, as observed at residue Phe25 in the IGF-I crystal structure. These alterations should provide insight into the structural origins of insulin−IGF-I structural and functional divergence. The [TyrB25NMePheB26] mutant has been characterized, and its crystal structure has been determined. Surprisingly, all of these changes are well accommodated within an insulin R6 hexamer. Only one molecule of each dimer in the hexamer responds to the structural alterations, the other remaining very similar to wild-type insulin. All alterations, modest in their scale, cumulate in the C-terminal part of the B-chain (residues B23−B30), which moves toward the core of the insulin molecule and is associated with a significant shift of the A1 helix toward the C-terminus of the B-chain. These changes do not produce the expected bend of the main chain, but the fold of the mutant does reflect some structural characteristics of IGF-1, and in addition establishes the COA19−NHB25 hydrogen bond, which is normally characteristic of T-state insulin." @default.
• W1988412071 created "2016-06-24" @default.
• W1988412071 creator A5007156546 @default.
• W1988412071 creator A5028926573 @default.
• W1988412071 creator A5059555506 @default.
• W1988412071 creator A5064220061 @default.
• W1988412071 creator A5074423495 @default.
• W1988412071 creator A5079725454 @default.
• W1988412071 creator A5082265822 @default.
• W1988412071 date "2004-11-25" @default.
• W1988412071 modified "2023-10-03" @default.
• W1988412071 title "Toward the Insulin−IGF-I Intermediate Structures: Functional and Structural Properties of the [Tyr^B25NMePhe^B26] Insulin Mutant" @default.
• W1988412071 cites W1515799994 @default.
• W1988412071 cites W1560164243 @default.
• W1988412071 cites W1571293525 @default.
• W1988412071 cites W1626530869 @default.
• W1988412071 cites W1807852583 @default.
• W1988412071 cites W1978690212 @default.
• W1988412071 cites W1986191025 @default.
• W1988412071 cites W1986749099 @default.
• W1988412071 cites W1993133029 @default.
• W1988412071 cites W1994924757 @default.
• W1988412071 cites W2005749906 @default.
• W1988412071 cites W2009453211 @default.
• W1988412071 cites W2010296481 @default.
• W1988412071 cites W2028231353 @default.
• W1988412071 cites W2031450195 @default.
• W1988412071 cites W2038840577 @default.
• W1988412071 cites W2045494876 @default.
• W1988412071 cites W2049214916 @default.
• W1988412071 cites W2067284038 @default.
• W1988412071 cites W2080476827 @default.
• W1988412071 cites W2084575458 @default.
• W1988412071 cites W2092045587 @default.
• W1988412071 cites W2092643236 @default.
• W1988412071 cites W2092817365 @default.
• W1988412071 cites W2097493124 @default.
• W1988412071 cites W2111160721 @default.
• W1988412071 cites W2120726576 @default.
• W1988412071 cites W2148364094 @default.
• W1988412071 cites W2326674964 @default.
• W1988412071 cites W2328833755 @default.
• W1988412071 cites W2329136971 @default.
• W1988412071 cites W2418356371 @default.
• W1988412071 cites W2950651273 @default.
• W1988412071 cites W2029374758 @default.
• W1988412071 cites W2054767977 @default.
• W1988412071 doi "https://doi.org/10.1021/bi048856u" @default.
• W1988412071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15610023" @default.
• W1988412071 hasPublicationYear "2004" @default.
• W1988412071 type Work @default.
• W1988412071 sameAs 1988412071 @default.
• W1988412071 citedByCount "9" @default.
• W1988412071 countsByYear W19884120712012 @default.
• W1988412071 countsByYear W19884120712016 @default.
• W1988412071 countsByYear W19884120712023 @default.
• W1988412071 crossrefType "journal-article" @default.
• W1988412071 hasAuthorship W1988412071A5007156546 @default.
• W1988412071 hasAuthorship W1988412071A5028926573 @default.
• W1988412071 hasAuthorship W1988412071A5059555506 @default.
• W1988412071 hasAuthorship W1988412071A5064220061 @default.
• W1988412071 hasAuthorship W1988412071A5074423495 @default.
• W1988412071 hasAuthorship W1988412071A5079725454 @default.
• W1988412071 hasAuthorship W1988412071A5082265822 @default.
• W1988412071 hasConcept C104317684 @default.
• W1988412071 hasConcept C134018914 @default.
• W1988412071 hasConcept C143065580 @default.
• W1988412071 hasConcept C170493617 @default.
• W1988412071 hasConcept C178790620 @default.
• W1988412071 hasConcept C185592680 @default.
• W1988412071 hasConcept C189754071 @default.
• W1988412071 hasConcept C2775960820 @default.
• W1988412071 hasConcept C2779306644 @default.
• W1988412071 hasConcept C2779546866 @default.
• W1988412071 hasConcept C2780331951 @default.
• W1988412071 hasConcept C2780689927 @default.
• W1988412071 hasConcept C55493867 @default.
• W1988412071 hasConcept C71240020 @default.
• W1988412071 hasConcept C86803240 @default.
• W1988412071 hasConceptScore W1988412071C104317684 @default.
• W1988412071 hasConceptScore W1988412071C134018914 @default.
• W1988412071 hasConceptScore W1988412071C143065580 @default.
• W1988412071 hasConceptScore W1988412071C170493617 @default.
• W1988412071 hasConceptScore W1988412071C178790620 @default.
• W1988412071 hasConceptScore W1988412071C185592680 @default.
• W1988412071 hasConceptScore W1988412071C189754071 @default.
• W1988412071 hasConceptScore W1988412071C2775960820 @default.
• W1988412071 hasConceptScore W1988412071C2779306644 @default.
• W1988412071 hasConceptScore W1988412071C2779546866 @default.
• W1988412071 hasConceptScore W1988412071C2780331951 @default.
• W1988412071 hasConceptScore W1988412071C2780689927 @default.
• W1988412071 hasConceptScore W1988412071C55493867 @default.
• W1988412071 hasConceptScore W1988412071C71240020 @default.
• W1988412071 hasConceptScore W1988412071C86803240 @default.
• W1988412071 hasIssue "51" @default.
• W1988412071 hasLocation W19884120711 @default.
• W1988412071 hasLocation W19884120712 @default.
• W1988412071 hasOpenAccess W1988412071 @default.

• next