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• W1988441109 abstract "High-speed chronoamperometry was used to monitor dopamine-related electrochemical signals in the nucleus accumbens of rats allowed to self-administer heroin intravenously and rats that received similar injections passively. Rats self-administered 100 μg/kg of heroin at ∼20-min intervals. Dopamine-related electrochemical signals increased monotonically after the first injection of each day; the effect was weaker on the first than on the second and subsequent days. The second and subsequent injections in each session caused biphasic effects: the initial effect was a decrease in signal-a minor one when compared to the increase caused by the first injection-and this was followed by an increase that brought the signal back to or somewhat higher than the level at the time of the injection. Over the course of each 4-h session, the electrochemical signal reached and fluctuated around an elevated plateau; doubling the injection dose did not elevate this plateau but did cause larger phasic decreases and subsequent increases. Qualitatively similar electrochemical changes were seen in the animals passively receiving the drug, but there were two notable quantitative differences. First, in the passive animals the initial depressions in signal were of shorter duration. Second, in the passive animals (which were injected at intervals determined by the self-administering animals) the electrochemical signal reached a maximum and began to fall prior to the time of the next injection; in the animals that self-administered the drug, the signal was still rising at the time of the next injection. The changes in electrochemical signal are unlikely to represent fluctuations of ascorbate or dopamine metabolites; thus it appears that whereas self-administered heroin injections cause a slow and long-lasting elevation of extracellular dopamine concentration, short-term increases in dopamine concentration are associated with the behavioral activation that precedes the injections and it is short-term decreases that appear to be associated with the period usually thought to be most significant for positive reinforcement. © 1993 Wiley-Liss, Inc." @default.
• W1988441109 created "2016-06-24" @default.
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• W1988441109 date "1993-05-01" @default.
• W1988441109 modified "2023-09-25" @default.
• W1988441109 title "Drug- and behavior-associated changes in dopamine-related electrochemical signals during intravenous heroin self-administration in rats" @default.
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• W1988441109 cites W1810663112 @default.
• W1988441109 cites W1918339224 @default.
• W1988441109 cites W1961847285 @default.
• W1988441109 cites W1965926569 @default.
• W1988441109 cites W1970179542 @default.
• W1988441109 cites W1978232917 @default.
• W1988441109 cites W1979399407 @default.
• W1988441109 cites W1979684634 @default.
• W1988441109 cites W1981648513 @default.
• W1988441109 cites W1982019262 @default.
• W1988441109 cites W1982272270 @default.
• W1988441109 cites W1984153476 @default.
• W1988441109 cites W1984366994 @default.
• W1988441109 cites W1985803034 @default.
• W1988441109 cites W1986023449 @default.
• W1988441109 cites W1988880636 @default.
• W1988441109 cites W1996108093 @default.
• W1988441109 cites W1996762183 @default.
• W1988441109 cites W2004713725 @default.
• W1988441109 cites W2004867172 @default.
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• W1988441109 cites W2023221544 @default.
• W1988441109 cites W2025068728 @default.
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• W1988441109 cites W2033900300 @default.
• W1988441109 cites W2036538596 @default.
• W1988441109 cites W2040132819 @default.
• W1988441109 cites W2046837952 @default.
• W1988441109 cites W2048538659 @default.
• W1988441109 cites W2048761114 @default.
• W1988441109 cites W2049854645 @default.
• W1988441109 cites W2051188685 @default.
• W1988441109 cites W2053940880 @default.
• W1988441109 cites W2061161259 @default.
• W1988441109 cites W2061418383 @default.
• W1988441109 cites W2066105521 @default.
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• W1988441109 cites W2081167840 @default.
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• W1988441109 cites W2101013421 @default.
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• W1988441109 doi "https://doi.org/10.1002/syn.890140109" @default.
• W1988441109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8511719" @default.
• W1988441109 hasPublicationYear "1993" @default.
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