FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988442672> ?p ?o ?g. }

• W1988442672 endingPage "3502" @default.
• W1988442672 startingPage "3495" @default.
• W1988442672 abstract "Host defense peptides (HDPs), part of the innate immune system, selectively target the membranes of bacterial cells over that of host cells. As a result, their antimicrobial properties have been under intense study. Their selectivity strongly depends on the chemical and mostly structural properties of the lipids that make up different cell membranes. The ability to synthesize HDP mimics has recently been demonstrated. To better understand how these HDP mimics interact with bilayer membranes, three homologous antimicrobial oligomers (AMOs) 1-3 with an m-phenylene ethynylene backbone and alkyl amine side chains were studied. Among them, AMO 1 is nonactive, AMO 2 is specifically active, and AMO 3 is nonspecifically active against bacteria over human red blood cells, a standard model for mammalian cells. The interactions of these three AMOs with liposomes having different lipid compositions are characterized in detail using a fluorescent dye leakage assay. AMO 2 and AMO 3 caused more leakage than AMO 1 from bacteria membrane mimic liposomes composed of PE/PG lipids. The use of E. coli lipid vesicles gave the same results. Further changes of the lipid compositions revealed that AMO 2 has selectively higher affinity toward PE/PG and E. coli lipids than PC, PC/PG or PC/PS lipids, the major components of mammalian cell membranes. In contrast, AMO 3 is devoid of this lipid selectivity and interacts with all liposomes with equal ease; AMO 1 remains inactive. These observations suggest that lipid type and structure are more important in determining membrane selectivity than lipid headgroup charges for this series of HDP mimics." @default.
• W1988442672 created "2016-06-24" @default.
• W1988442672 creator A5057790361 @default.
• W1988442672 creator A5086363084 @default.
• W1988442672 date "2008-02-23" @default.
• W1988442672 modified "2023-09-26" @default.
• W1988442672 title "Influence of Lipid Composition on Membrane Activity of Antimicrobial Phenylene Ethynylene Oligomers" @default.
• W1988442672 cites W1501359805 @default.
• W1988442672 cites W1858651405 @default.
• W1988442672 cites W1971756197 @default.
• W1988442672 cites W1975313075 @default.
• W1988442672 cites W1989642335 @default.
• W1988442672 cites W1990233153 @default.
• W1988442672 cites W1996507856 @default.
• W1988442672 cites W1998404949 @default.
• W1988442672 cites W2001374696 @default.
• W1988442672 cites W2002066211 @default.
• W1988442672 cites W2006400094 @default.
• W1988442672 cites W2008502035 @default.
• W1988442672 cites W2010100886 @default.
• W1988442672 cites W2017268899 @default.
• W1988442672 cites W2021198082 @default.
• W1988442672 cites W2030597389 @default.
• W1988442672 cites W2032233723 @default.
• W1988442672 cites W2036628662 @default.
• W1988442672 cites W2045247642 @default.
• W1988442672 cites W2046813153 @default.
• W1988442672 cites W2047051687 @default.
• W1988442672 cites W2050140989 @default.
• W1988442672 cites W2052148977 @default.
• W1988442672 cites W2052300481 @default.
• W1988442672 cites W2054602599 @default.
• W1988442672 cites W2056013343 @default.
• W1988442672 cites W2070632568 @default.
• W1988442672 cites W2072167784 @default.
• W1988442672 cites W2073894126 @default.
• W1988442672 cites W2075518645 @default.
• W1988442672 cites W2081277508 @default.
• W1988442672 cites W2082492607 @default.
• W1988442672 cites W2082948099 @default.
• W1988442672 cites W2083443165 @default.
• W1988442672 cites W2085542920 @default.
• W1988442672 cites W2087043215 @default.
• W1988442672 cites W2092295885 @default.
• W1988442672 cites W2121417680 @default.
• W1988442672 cites W2122080717 @default.
• W1988442672 cites W2136277094 @default.
• W1988442672 cites W2155595547 @default.
• W1988442672 cites W2165500804 @default.
• W1988442672 cites W4238374804 @default.
• W1988442672 doi "https://doi.org/10.1021/jp077487j" @default.
• W1988442672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3774278" @default.
• W1988442672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18293958" @default.
• W1988442672 hasPublicationYear "2008" @default.
• W1988442672 type Work @default.
• W1988442672 sameAs 1988442672 @default.
• W1988442672 citedByCount "102" @default.
• W1988442672 countsByYear W19884426722012 @default.
• W1988442672 countsByYear W19884426722013 @default.
• W1988442672 countsByYear W19884426722014 @default.
• W1988442672 countsByYear W19884426722015 @default.
• W1988442672 countsByYear W19884426722016 @default.
• W1988442672 countsByYear W19884426722017 @default.
• W1988442672 countsByYear W19884426722018 @default.
• W1988442672 countsByYear W19884426722019 @default.
• W1988442672 countsByYear W19884426722020 @default.
• W1988442672 countsByYear W19884426722021 @default.
• W1988442672 countsByYear W19884426722022 @default.
• W1988442672 countsByYear W19884426722023 @default.
• W1988442672 crossrefType "journal-article" @default.
• W1988442672 hasAuthorship W1988442672A5057790361 @default.
• W1988442672 hasAuthorship W1988442672A5086363084 @default.
• W1988442672 hasBestOaLocation W19884426722 @default.
• W1988442672 hasConcept C107565407 @default.
• W1988442672 hasConcept C12554922 @default.
• W1988442672 hasConcept C130316041 @default.
• W1988442672 hasConcept C178790620 @default.
• W1988442672 hasConcept C185154212 @default.
• W1988442672 hasConcept C185592680 @default.
• W1988442672 hasConcept C2776026683 @default.
• W1988442672 hasConcept C39944091 @default.
• W1988442672 hasConcept C41625074 @default.
• W1988442672 hasConcept C4937899 @default.
• W1988442672 hasConcept C521977710 @default.
• W1988442672 hasConcept C55493867 @default.
• W1988442672 hasConcept C86803240 @default.
• W1988442672 hasConceptScore W1988442672C107565407 @default.
• W1988442672 hasConceptScore W1988442672C12554922 @default.
• W1988442672 hasConceptScore W1988442672C130316041 @default.
• W1988442672 hasConceptScore W1988442672C178790620 @default.
• W1988442672 hasConceptScore W1988442672C185154212 @default.
• W1988442672 hasConceptScore W1988442672C185592680 @default.
• W1988442672 hasConceptScore W1988442672C2776026683 @default.
• W1988442672 hasConceptScore W1988442672C39944091 @default.
• W1988442672 hasConceptScore W1988442672C41625074 @default.
• W1988442672 hasConceptScore W1988442672C4937899 @default.
• W1988442672 hasConceptScore W1988442672C521977710 @default.
• W1988442672 hasConceptScore W1988442672C55493867 @default.

• next