Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988443154> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1988443154 abstract "CD40 and CD154 belong to the tumor necrosis factor (TNF) receptor superfamily and the TNF superfamily, respectively. Evidence is accumulating that indicates the importance of this receptor-ligand pair in the immunopathogenesis of autoimmune diseases. The CD40-CD154 interaction influences antigen presentation, tolerance, autoantibody production and tissue damage, all of which are relevant to the development and perpetuation of autoimmune diseases. Among the collagen diseases, the CD40-CD154 interaction has been intensively investigated in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). In this article, both basic and clinical research suggesting the involvement of the CD40-CD154 interaction in SLE, RA, inflammatory myopathies, systemic sclerosis and antiphospholipid syndrome are reviewed. The results of clinical trials from CD40-CD154 blockade are also analyzed. CD40-CD154 blockade in animal models of autoimmune diseases has been reported to be a promising novel therapeutic approach and, thus, has attracted great attention from pharmaceutical companies. However, the development of CD40-CD154 blockers with both significant clinical efficacy and safety has not been successful and research advances in this field are eagerly awaited." @default.
- W1988443154 created "2016-06-24" @default.
- W1988443154 creator A5078737545 @default.
- W1988443154 date "2004-01-01" @default.
- W1988443154 modified "2023-09-25" @default.
- W1988443154 title "Involvement of CD40-CD154 interaction in immunopathogenesis of collagen diseases and its application to a novel therapeutic strategy" @default.
- W1988443154 cites W1512393880 @default.
- W1988443154 cites W1514664819 @default.
- W1988443154 cites W1525199620 @default.
- W1988443154 cites W1539498191 @default.
- W1988443154 cites W1540980176 @default.
- W1988443154 cites W1560479977 @default.
- W1988443154 cites W1561516029 @default.
- W1988443154 cites W1565951988 @default.
- W1988443154 cites W1606436237 @default.
- W1988443154 cites W1648230854 @default.
- W1988443154 cites W1801041910 @default.
- W1988443154 cites W1804074798 @default.
- W1988443154 cites W1861264478 @default.
- W1988443154 cites W18636088 @default.
- W1988443154 cites W1963910613 @default.
- W1988443154 cites W1969979568 @default.
- W1988443154 cites W1974517452 @default.
- W1988443154 cites W1989198058 @default.
- W1988443154 cites W1989716637 @default.
- W1988443154 cites W1995671438 @default.
- W1988443154 cites W2009154052 @default.
- W1988443154 cites W2010610200 @default.
- W1988443154 cites W2019577361 @default.
- W1988443154 cites W2029957805 @default.
- W1988443154 cites W2042441746 @default.
- W1988443154 cites W2052803753 @default.
- W1988443154 cites W2056153386 @default.
- W1988443154 cites W2056617362 @default.
- W1988443154 cites W2062079622 @default.
- W1988443154 cites W2062476933 @default.
- W1988443154 cites W2062563784 @default.
- W1988443154 cites W2063661003 @default.
- W1988443154 cites W2066401208 @default.
- W1988443154 cites W2068488477 @default.
- W1988443154 cites W2085534168 @default.
- W1988443154 cites W2100186575 @default.
- W1988443154 cites W2103928142 @default.
- W1988443154 cites W2109044040 @default.
- W1988443154 cites W2135376096 @default.
- W1988443154 cites W2165467521 @default.
- W1988443154 cites W2273258602 @default.
- W1988443154 cites W2282446275 @default.
- W1988443154 cites W2414546283 @default.
- W1988443154 cites W276577763 @default.
- W1988443154 cites W2993535786 @default.
- W1988443154 cites W3213082070 @default.
- W1988443154 doi "https://doi.org/10.2177/jsci.27.379" @default.
- W1988443154 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15678891" @default.
- W1988443154 hasPublicationYear "2004" @default.
- W1988443154 type Work @default.
- W1988443154 sameAs 1988443154 @default.
- W1988443154 citedByCount "0" @default.
- W1988443154 crossrefType "journal-article" @default.
- W1988443154 hasAuthorship W1988443154A5078737545 @default.
- W1988443154 hasBestOaLocation W19884431541 @default.
- W1988443154 hasConcept C154317977 @default.
- W1988443154 hasConcept C185592680 @default.
- W1988443154 hasConcept C202751555 @default.
- W1988443154 hasConcept C2779234475 @default.
- W1988443154 hasConcept C39347974 @default.
- W1988443154 hasConcept C55493867 @default.
- W1988443154 hasConcept C71924100 @default.
- W1988443154 hasConceptScore W1988443154C154317977 @default.
- W1988443154 hasConceptScore W1988443154C185592680 @default.
- W1988443154 hasConceptScore W1988443154C202751555 @default.
- W1988443154 hasConceptScore W1988443154C2779234475 @default.
- W1988443154 hasConceptScore W1988443154C39347974 @default.
- W1988443154 hasConceptScore W1988443154C55493867 @default.
- W1988443154 hasConceptScore W1988443154C71924100 @default.
- W1988443154 hasLocation W19884431541 @default.
- W1988443154 hasLocation W19884431542 @default.
- W1988443154 hasOpenAccess W1988443154 @default.
- W1988443154 hasPrimaryLocation W19884431541 @default.
- W1988443154 hasRelatedWork W1978683506 @default.
- W1988443154 hasRelatedWork W2053113431 @default.
- W1988443154 hasRelatedWork W2069587915 @default.
- W1988443154 hasRelatedWork W2083730628 @default.
- W1988443154 hasRelatedWork W2123641407 @default.
- W1988443154 hasRelatedWork W2124655219 @default.
- W1988443154 hasRelatedWork W2167420194 @default.
- W1988443154 hasRelatedWork W2231748200 @default.
- W1988443154 hasRelatedWork W2412165247 @default.
- W1988443154 hasRelatedWork W2762492131 @default.
- W1988443154 isParatext "false" @default.
- W1988443154 isRetracted "false" @default.
- W1988443154 magId "1988443154" @default.
- W1988443154 workType "article" @default.