FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988447508> ?p ?o ?g. }

• W1988447508 abstract "SPRY4-IT1 has been reported to have extremely high expression in normal placenta tissues. It is a Long noncoding RNA (lncRNA), which is associated with cell growth, migration, invasion, and apoptosis in melanoma. A 2.8-fold increase of SPRY4-IT1 expression was validated by Real-time reverse transcription-polymerase chain reaction (qRT-PCR) in severe preeclamptic placenta as compared with that of the normal ones (n=25) in this study. Furthermore, the role of SPRY4-IT1 in proliferation, migration, apoptosis, and network formation ability of trophoblast cells HTR-8/SVneo was assessed. Suppression of SPRY4-IT1 using siRNA treatment and its overexpression using plasmid targeting SPRY4-IT1 were performed in order to explore the biological function of SPRY4-IT1 in the development and progression of trophoblast cells HTR-8/SVneo, in vitro. The results showed that SPRY4-IT1 knockdown enhanced the cell migration and proliferation, and reduced the response of cells to apoptosis. However, exogenous SPRY4-IT1 overexpression significantly decreased the cell migration and proliferation, while increased cell apoptosis. Our study showed for the first time that aberrant expression of lncRNA SPRY4-IT1 might contribute to the abnormal condition of trophoblast cells HTR-8/SVneo. Therefore, we proposed SPRY4-IT1 as a novel lncRNA molecule, which might be associated with the pathogenesis of preeclampsia and might provide a new target for its early diagnosis and treatment." @default.
• W1988447508 created "2016-06-24" @default.
• W1988447508 creator A5005338744 @default.
• W1988447508 creator A5015152308 @default.
• W1988447508 creator A5041934647 @default.
• W1988447508 creator A5044531468 @default.
• W1988447508 creator A5045906060 @default.
• W1988447508 creator A5061199980 @default.
• W1988447508 creator A5061458791 @default.
• W1988447508 creator A5063212646 @default.
• W1988447508 creator A5076673988 @default.
• W1988447508 creator A5079611254 @default.
• W1988447508 creator A5085712319 @default.
• W1988447508 creator A5091537321 @default.
• W1988447508 date "2013-01-01" @default.
• W1988447508 modified "2023-10-13" @default.
• W1988447508 title "Upregulation of long noncoding RNA SPRY4-IT1 modulates proliferation, migration, apoptosis, and network formation in trophoblast cells HTR-8SV/neo." @default.
• W1988447508 cites W1973445288 @default.
• W1988447508 cites W1973905104 @default.
• W1988447508 cites W1975195151 @default.
• W1988447508 cites W1977551072 @default.
• W1988447508 cites W1980247868 @default.
• W1988447508 cites W1980772646 @default.
• W1988447508 cites W1982658831 @default.
• W1988447508 cites W1987906374 @default.
• W1988447508 cites W1989904037 @default.
• W1988447508 cites W1994169529 @default.
• W1988447508 cites W2000197014 @default.
• W1988447508 cites W2010253027 @default.
• W1988447508 cites W2016302314 @default.
• W1988447508 cites W2017648684 @default.
• W1988447508 cites W2017904618 @default.
• W1988447508 cites W2018430931 @default.
• W1988447508 cites W2020833385 @default.
• W1988447508 cites W2023373744 @default.
• W1988447508 cites W2030047242 @default.
• W1988447508 cites W2035365585 @default.
• W1988447508 cites W2047333953 @default.
• W1988447508 cites W2049536473 @default.
• W1988447508 cites W2052308608 @default.
• W1988447508 cites W2061427860 @default.
• W1988447508 cites W2063827788 @default.
• W1988447508 cites W2064551554 @default.
• W1988447508 cites W2069353776 @default.
• W1988447508 cites W2071271349 @default.
• W1988447508 cites W2074613286 @default.
• W1988447508 cites W2089652064 @default.
• W1988447508 cites W2099468911 @default.
• W1988447508 cites W2101378716 @default.
• W1988447508 cites W2102881826 @default.
• W1988447508 cites W2104123431 @default.
• W1988447508 cites W2113400357 @default.
• W1988447508 cites W2116806083 @default.
• W1988447508 cites W2126504590 @default.
• W1988447508 cites W2127300943 @default.
• W1988447508 cites W2127744901 @default.
• W1988447508 cites W2130876190 @default.
• W1988447508 cites W2133547019 @default.
• W1988447508 cites W2136725005 @default.
• W1988447508 cites W2137840425 @default.
• W1988447508 cites W2144137532 @default.
• W1988447508 cites W2145931730 @default.
• W1988447508 cites W2146573461 @default.
• W1988447508 cites W2148750389 @default.
• W1988447508 cites W2150695488 @default.
• W1988447508 doi "https://doi.org/10.1371/journal.pone.0079598" @default.
• W1988447508 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3819274" @default.
• W1988447508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24223182" @default.
• W1988447508 hasPublicationYear "2013" @default.
• W1988447508 type Work @default.
• W1988447508 sameAs 1988447508 @default.
• W1988447508 citedByCount "83" @default.
• W1988447508 countsByYear W19884475082014 @default.
• W1988447508 countsByYear W19884475082015 @default.
• W1988447508 countsByYear W19884475082016 @default.
• W1988447508 countsByYear W19884475082017 @default.
• W1988447508 countsByYear W19884475082018 @default.
• W1988447508 countsByYear W19884475082019 @default.
• W1988447508 countsByYear W19884475082020 @default.
• W1988447508 countsByYear W19884475082021 @default.
• W1988447508 countsByYear W19884475082022 @default.
• W1988447508 countsByYear W19884475082023 @default.
• W1988447508 crossrefType "journal-article" @default.
• W1988447508 hasAuthorship W1988447508A5005338744 @default.
• W1988447508 hasAuthorship W1988447508A5015152308 @default.
• W1988447508 hasAuthorship W1988447508A5041934647 @default.
• W1988447508 hasAuthorship W1988447508A5044531468 @default.
• W1988447508 hasAuthorship W1988447508A5045906060 @default.
• W1988447508 hasAuthorship W1988447508A5061199980 @default.
• W1988447508 hasAuthorship W1988447508A5061458791 @default.
• W1988447508 hasAuthorship W1988447508A5063212646 @default.
• W1988447508 hasAuthorship W1988447508A5076673988 @default.
• W1988447508 hasAuthorship W1988447508A5079611254 @default.
• W1988447508 hasAuthorship W1988447508A5085712319 @default.
• W1988447508 hasAuthorship W1988447508A5091537321 @default.
• W1988447508 hasBestOaLocation W19884475081 @default.
• W1988447508 hasConcept C104317684 @default.
• W1988447508 hasConcept C127561419 @default.
• W1988447508 hasConcept C172680121 @default.
• W1988447508 hasConcept C173396325 @default.

• next