Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988452823> ?p ?o ?g. }
- W1988452823 endingPage "501" @default.
- W1988452823 startingPage "495" @default.
- W1988452823 abstract "Increasing evidence that several drug compounds exert their effects through interactions with multiple targets is boosting the development of research fields that challenge the data reductionism approach. In this article, we review and discuss the concepts of drug repurposing, polypharmacology, chemogenomics, phenotypic screening and high-throughput in vivo testing of mixture-based libraries in an integrated manner. These research fields offer alternatives to the current paradigm of drug discovery, from a one target–one drug model to a multiple-target approach. Furthermore, the goals of lead identification are being expanded accordingly to identify not only ‘key’ compounds that fit with a single-target ‘lock’, but also ‘master key’ compounds that favorably interact with multiple targets (i.e. operate a set of desired locks to gain access to the expected clinical effects)." @default.
- W1988452823 created "2016-06-24" @default.
- W1988452823 creator A5005431998 @default.
- W1988452823 creator A5047419813 @default.
- W1988452823 creator A5064005826 @default.
- W1988452823 creator A5086421148 @default.
- W1988452823 date "2013-05-01" @default.
- W1988452823 modified "2023-10-17" @default.
- W1988452823 title "Shifting from the single to the multitarget paradigm in drug discovery" @default.
- W1988452823 cites W1493055596 @default.
- W1988452823 cites W1971527053 @default.
- W1988452823 cites W1972821149 @default.
- W1988452823 cites W1973754681 @default.
- W1988452823 cites W1973974137 @default.
- W1988452823 cites W1980047995 @default.
- W1988452823 cites W1981076832 @default.
- W1988452823 cites W1987730034 @default.
- W1988452823 cites W1991833480 @default.
- W1988452823 cites W1992787746 @default.
- W1988452823 cites W1992960758 @default.
- W1988452823 cites W1995979404 @default.
- W1988452823 cites W1997959546 @default.
- W1988452823 cites W2005858009 @default.
- W1988452823 cites W2006281337 @default.
- W1988452823 cites W2007249694 @default.
- W1988452823 cites W2008732224 @default.
- W1988452823 cites W2009266771 @default.
- W1988452823 cites W2016657267 @default.
- W1988452823 cites W2020796560 @default.
- W1988452823 cites W2033100449 @default.
- W1988452823 cites W2033159584 @default.
- W1988452823 cites W2033591223 @default.
- W1988452823 cites W2036831677 @default.
- W1988452823 cites W2040369353 @default.
- W1988452823 cites W2040860367 @default.
- W1988452823 cites W2044790426 @default.
- W1988452823 cites W2046581055 @default.
- W1988452823 cites W2051137721 @default.
- W1988452823 cites W2053588896 @default.
- W1988452823 cites W2057625601 @default.
- W1988452823 cites W2061455471 @default.
- W1988452823 cites W2061457917 @default.
- W1988452823 cites W2062941476 @default.
- W1988452823 cites W2065331570 @default.
- W1988452823 cites W2076098814 @default.
- W1988452823 cites W2079971015 @default.
- W1988452823 cites W2080824085 @default.
- W1988452823 cites W2081219988 @default.
- W1988452823 cites W2082487625 @default.
- W1988452823 cites W2085809352 @default.
- W1988452823 cites W2094346750 @default.
- W1988452823 cites W2095272886 @default.
- W1988452823 cites W2111581388 @default.
- W1988452823 cites W2114445615 @default.
- W1988452823 cites W2116238734 @default.
- W1988452823 cites W2117682071 @default.
- W1988452823 cites W2140972311 @default.
- W1988452823 cites W2141749176 @default.
- W1988452823 cites W2152864198 @default.
- W1988452823 cites W2161782568 @default.
- W1988452823 cites W2168577803 @default.
- W1988452823 cites W2176516200 @default.
- W1988452823 cites W2315953949 @default.
- W1988452823 cites W2323987563 @default.
- W1988452823 cites W2325179027 @default.
- W1988452823 cites W2949427142 @default.
- W1988452823 cites W4252181201 @default.
- W1988452823 doi "https://doi.org/10.1016/j.drudis.2013.01.008" @default.
- W1988452823 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3642214" @default.
- W1988452823 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23340113" @default.
- W1988452823 hasPublicationYear "2013" @default.
- W1988452823 type Work @default.
- W1988452823 sameAs 1988452823 @default.
- W1988452823 citedByCount "364" @default.
- W1988452823 countsByYear W19884528232013 @default.
- W1988452823 countsByYear W19884528232014 @default.
- W1988452823 countsByYear W19884528232015 @default.
- W1988452823 countsByYear W19884528232016 @default.
- W1988452823 countsByYear W19884528232017 @default.
- W1988452823 countsByYear W19884528232018 @default.
- W1988452823 countsByYear W19884528232019 @default.
- W1988452823 countsByYear W19884528232020 @default.
- W1988452823 countsByYear W19884528232021 @default.
- W1988452823 countsByYear W19884528232022 @default.
- W1988452823 countsByYear W19884528232023 @default.
- W1988452823 crossrefType "journal-article" @default.
- W1988452823 hasAuthorship W1988452823A5005431998 @default.
- W1988452823 hasAuthorship W1988452823A5047419813 @default.
- W1988452823 hasAuthorship W1988452823A5064005826 @default.
- W1988452823 hasAuthorship W1988452823A5086421148 @default.
- W1988452823 hasBestOaLocation W19884528232 @default.
- W1988452823 hasConcept C103637391 @default.
- W1988452823 hasConcept C116834253 @default.
- W1988452823 hasConcept C119857082 @default.
- W1988452823 hasConcept C18903297 @default.
- W1988452823 hasConcept C2522767166 @default.
- W1988452823 hasConcept C26517878 @default.
- W1988452823 hasConcept C2780035454 @default.