Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988461845> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1988461845 endingPage "252" @default.
- W1988461845 startingPage "248" @default.
- W1988461845 abstract "Purpose: 5-Fluorouracil (5-FU) is used intraoperatively to improve the success of trabeculectomy. Common practice is a 5-min application of 5-FU delivered via a Weck Cel sponge. The aim of this study was to determine if shorter exposure times were as effective in inhibiting Tenon’s capsule fibroblast proliferation. Methods: Samples of Tenon’s capsules, obtained from young patients undergoing strabismus surgery, were immersed in vitro in 5-FU (50 mg/mL) for periods ranging from 1 to 10 min. Control samples were exposed either to growth medium (M199) or 5-FU vehicle alone. Explants were cultured for up to 7 days and analysed for cell density, cell viability using fluoroprobe detection, and cell proliferation determined by proliferating cell nuclear antigen (PCNA)-staining. Results: Exposure to 5-FU for 1 and 5 min resulted in a similar and significant inhibition of the culture-induced increase in stromal cell density (P < 0.01), a significant reduction in the percentage of viable cells (P < 0.02), and reduced PCNA indices, compared with controls. Exposure times of 3 and 10 min produced similar results. Conclusions: In vitro, under conditions of organ culture, a 1-min exposure to 5-FU had a significant antiproliferative effect on fibroblasts of Tenon’s capsule, and was similar to 5 min of exposure. Optimal intraoperative 5-FU exposure time may be as little as 1 minute." @default.
- W1988461845 created "2016-06-24" @default.
- W1988461845 creator A5053937903 @default.
- W1988461845 creator A5055081098 @default.
- W1988461845 creator A5062510480 @default.
- W1988461845 creator A5086104876 @default.
- W1988461845 date "2001-08-01" @default.
- W1988461845 modified "2023-09-25" @default.
- W1988461845 title "Effects of varying 5-fluorouracil exposure duration on Tenon's capsule fibroblasts" @default.
- W1988461845 cites W1544354993 @default.
- W1988461845 cites W1982857854 @default.
- W1988461845 cites W1988612232 @default.
- W1988461845 cites W2010164749 @default.
- W1988461845 cites W2059878801 @default.
- W1988461845 cites W2150784458 @default.
- W1988461845 cites W3142292247 @default.
- W1988461845 doi "https://doi.org/10.1046/j.1442-9071.2001.00422.x" @default.
- W1988461845 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11545425" @default.
- W1988461845 hasPublicationYear "2001" @default.
- W1988461845 type Work @default.
- W1988461845 sameAs 1988461845 @default.
- W1988461845 citedByCount "7" @default.
- W1988461845 countsByYear W19884618452015 @default.
- W1988461845 crossrefType "journal-article" @default.
- W1988461845 hasAuthorship W1988461845A5053937903 @default.
- W1988461845 hasAuthorship W1988461845A5055081098 @default.
- W1988461845 hasAuthorship W1988461845A5062510480 @default.
- W1988461845 hasAuthorship W1988461845A5086104876 @default.
- W1988461845 hasConcept C118487528 @default.
- W1988461845 hasConcept C127413603 @default.
- W1988461845 hasConcept C142724271 @default.
- W1988461845 hasConcept C154049752 @default.
- W1988461845 hasConcept C16685009 @default.
- W1988461845 hasConcept C202751555 @default.
- W1988461845 hasConcept C204232928 @default.
- W1988461845 hasConcept C2778778583 @default.
- W1988461845 hasConcept C2780381497 @default.
- W1988461845 hasConcept C34688535 @default.
- W1988461845 hasConcept C53227056 @default.
- W1988461845 hasConcept C55493867 @default.
- W1988461845 hasConcept C59822182 @default.
- W1988461845 hasConcept C62112901 @default.
- W1988461845 hasConcept C66938386 @default.
- W1988461845 hasConcept C71924100 @default.
- W1988461845 hasConcept C74864618 @default.
- W1988461845 hasConcept C86803240 @default.
- W1988461845 hasConceptScore W1988461845C118487528 @default.
- W1988461845 hasConceptScore W1988461845C127413603 @default.
- W1988461845 hasConceptScore W1988461845C142724271 @default.
- W1988461845 hasConceptScore W1988461845C154049752 @default.
- W1988461845 hasConceptScore W1988461845C16685009 @default.
- W1988461845 hasConceptScore W1988461845C202751555 @default.
- W1988461845 hasConceptScore W1988461845C204232928 @default.
- W1988461845 hasConceptScore W1988461845C2778778583 @default.
- W1988461845 hasConceptScore W1988461845C2780381497 @default.
- W1988461845 hasConceptScore W1988461845C34688535 @default.
- W1988461845 hasConceptScore W1988461845C53227056 @default.
- W1988461845 hasConceptScore W1988461845C55493867 @default.
- W1988461845 hasConceptScore W1988461845C59822182 @default.
- W1988461845 hasConceptScore W1988461845C62112901 @default.
- W1988461845 hasConceptScore W1988461845C66938386 @default.
- W1988461845 hasConceptScore W1988461845C71924100 @default.
- W1988461845 hasConceptScore W1988461845C74864618 @default.
- W1988461845 hasConceptScore W1988461845C86803240 @default.
- W1988461845 hasIssue "4" @default.
- W1988461845 hasLocation W19884618451 @default.
- W1988461845 hasLocation W19884618452 @default.
- W1988461845 hasOpenAccess W1988461845 @default.
- W1988461845 hasPrimaryLocation W19884618451 @default.
- W1988461845 hasRelatedWork W1178713273 @default.
- W1988461845 hasRelatedWork W2072448326 @default.
- W1988461845 hasRelatedWork W2350724084 @default.
- W1988461845 hasRelatedWork W2350859482 @default.
- W1988461845 hasRelatedWork W2373082366 @default.
- W1988461845 hasRelatedWork W2387297220 @default.
- W1988461845 hasRelatedWork W2617189616 @default.
- W1988461845 hasRelatedWork W57467338 @default.
- W1988461845 hasRelatedWork W829688161 @default.
- W1988461845 hasRelatedWork W993167354 @default.
- W1988461845 hasVolume "29" @default.
- W1988461845 isParatext "false" @default.
- W1988461845 isRetracted "false" @default.
- W1988461845 magId "1988461845" @default.
- W1988461845 workType "article" @default.