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- W1988462015 abstract "The heterogeneity of breast cancer requires identification of novel genes that promote breast tumor development. Targeting such oncogenes therapeutically promises to improve clinical outcomes. We conducted an in vitro screen to identify human kinases that promote anchorage‐independent growth of immortalized human mammary epithelial cells. The screen is based on a transformation model that requires cooperative activation of the PI3K/AKT and MEK/ERK pathways. The pooled screen identified three transforming kinases - PTK6, PAK1 and CAMK4. The functions of these candidates in the PI3K/AKT and/or MEK/ERK pathways are being currently studied to determine their role in breast tumorigenesis. Citation Information: Cancer Res 2009;69(23 Suppl):A38." @default.
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- W1988462015 date "2009-12-01" @default.
- W1988462015 modified "2023-09-27" @default.
- W1988462015 title "Abstract A38: Human kinase screen for breast cancer oncogenes" @default.
- W1988462015 doi "https://doi.org/10.1158/0008-5472.fbcr09-a38" @default.
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