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• W1988475383 abstract "Abstract Cyclic mechanical stress (CMS) leads to alterations of cellular functions in the trabecular meshwork (TM), including the up‐regulation of transforming growth factor beta 1 (TGFβ1), that can potentially contribute to the pathogenesis of glaucoma. Although microRNAs (miRNAs) are known to play important roles in many biological functions, little is known about their potential involvement in the cellular responses elicited by mechanical stress. Here we analyzed changes in miRNA expression induced by CMS, and examined the possible role of miR‐24 in the response of human TM cells to CMS. CMS induced the expression of miR‐24 that led to the down regulation of the subtilisin‐like proprotein convertase FURIN, which is known to play a major role in the processing of TGFβ1. FURIN was confirmed as a novel target of miR‐24 by 3' UTR luciferase assay and western blot. Overexpression of miR‐24 resulted in a significant decrease in activated TGFβ1. This effect was mimicked by down regulation of FURIN by siRNA. Conversely, inhibition of miR‐24 expression with a specific antagomir led to a small but significant increase in TGFβ1. Furthermore, the increase in active TGFβ1 induced by CMS in HTM cells was prevented by miR‐24. Altogether, our results suggest that miRNAs might contribute to the regulation of responses to CMS in TM cells. Specifically, miR‐24 might play an important role in modulating the induction of TGFβ1 mediated by CMS through direct targeting of FURIN. J. Cell. Physiol. 226: 1407–1414, 2011. © 2010 Wiley‐Liss, Inc." @default.
• W1988475383 created "2016-06-24" @default.
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• W1988475383 date "2011-02-22" @default.
• W1988475383 modified "2023-10-18" @default.
• W1988475383 title "MicroRNA-24 regulates the processing of latent TGFβ1 during cyclic mechanical stress in human trabecular meshwork cells through direct targeting of FURIN" @default.
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• W1988475383 doi "https://doi.org/10.1002/jcp.22476" @default.
• W1988475383 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3152464" @default.
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• W1988475383 hasPublicationYear "2011" @default.
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