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• W1988476412 endingPage "2004" @default.
• W1988476412 startingPage "1999" @default.
• W1988476412 abstract "The Na+ ionophore monensin affects cellular pH and, depending on its concentration, causes the survival or death of tumor cells. In the present study, we elucidated the survival pathway activated in U937 cells, a human lymphoma-derived cell line. These cells treated with monensin at a concentration of 5 µM were growth-arrested in G1, activated p38 mitogen-activated protein kinase (MAPK) and showed an increased expression of cyclooxygenase-2 (COX-2). The latter two molecular events were linked, as pharmacological inhibition of the MAPK did not allow COX-2 increased expression. Furthermore, we showed that p38 and COX-2 keep monensin-stressed U937 cells alive, as pharmacological inhibition of each enzyme caused cell death." @default.
• W1988476412 created "2016-06-24" @default.
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• W1988476412 date "2013-02-27" @default.
• W1988476412 modified "2023-10-17" @default.
• W1988476412 title "Cyclooxygenase-2 is induced by p38 MAPK and promotes cell survival" @default.
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• W1988476412 doi "https://doi.org/10.3892/or.2013.2308" @default.
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