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• W1988480635 abstract "The genes encoding the α1A, α1B, α1C and α1E subunits of neuronal high voltage-gated Ca channels (HVGCCs) were separately expressed with β1B and α2/δ subunits in Xenopus oocytes to determine the effects of volatile anesthetics (VAs) on currents through each specific channel. VA effects were determined on currents carried by Ba2+ (IBa) using the two electrode voltage clamp technique. Although time to peak was unaffected, both halothane (0.59 mM) and isoflurane (0.70 mM) reversibly inhibited peak IBa by 25–35% and late current (at 830 ms) by 50–60%. A hyperpolarizing shift in steady-state inactivation of α1E-current was found which could contribute up to one third of observed decrease in the peak current. The rate of inactivation of IBa seen with α1A, α1B and α1E-type Ca channels was consistently increased by halothane and isoflurane. To more clearly quantify these effects, IBa inactivation was fit by a single exponential function. The anesthetics depressed both the inactivating and non-inactivating residual components of IBa and decreased the time constant of inactivation. In the case of IBa through α1C-type channels, inactivation was minimal; however, the average current was inhibited by VAs. Similar inhibition of all these HVGCCs by halothane and isoflurane suggests that a common structural component may be involved. Furthermore, the inhibition of such neuronal HVGCCs in situ could alter synaptic neurotransmitter release and contribute to the anesthetic state." @default.
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• W1988480635 date "1999-06-01" @default.
• W1988480635 modified "2023-10-06" @default.
• W1988480635 title "Volatile anesthetic inhibition of neuronal Ca channel currents expressed in Xenopus oocytes" @default.
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• W1988480635 doi "https://doi.org/10.1016/s0006-8993(99)01401-8" @default.
• W1988480635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10411986" @default.
• W1988480635 hasPublicationYear "1999" @default.
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