FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988482775> ?p ?o ?g. }

• W1988482775 endingPage "e96238" @default.
• W1988482775 startingPage "e96238" @default.
• W1988482775 abstract "Rhabdomyosarcoma (RMS) is a pediatric myogenic-derived soft tissue sarcoma that includes two major histopathological subtypes: embryonal and alveolar. The majority of alveolar RMS expresses PAX3-FOXO1 fusion oncoprotein, associated with the worst prognosis. RMS cells show myogenic markers expression but are unable to terminally differentiate. The Notch signaling pathway is a master player during myogenesis, with Notch1 activation sustaining myoblast expansion and Notch3 activation inhibiting myoblast fusion and differentiation. Accordingly, Notch1 signaling is up-regulated and activated in embryonal RMS samples and supports the proliferation of tumor cells. However, it is unable to control their differentiation properties. We previously reported that Notch3 is activated in RMS cell lines, of both alveolar and embryonal subtype, and acts by inhibiting differentiation. Moreover, Notch3 depletion reduces PAX3-FOXO1 alveolar RMS tumor growth in vivo. However, whether Notch3 activation also sustains the proliferation of RMS cells remained unclear. To address this question, we forced the expression of the activated form of Notch3, Notch3IC, in the RH30 and RH41 PAX3-FOXO1-positive alveolar and in the RD embryonal RMS cell lines and studied the proliferation of these cells. We show that, in all three cell lines tested, Notch3IC over-expression stimulates in vitro cell proliferation and prevents the effects of pharmacological Notch inhibition. Furthermore, Notch3IC further increases RH30 cell growth in vivo. Interestingly, knockdown of Notch canonical ligands JAG1 or DLL1 in RMS cell lines decreases Notch3 activity and reduces cell proliferation. Finally, the expression of Notch3IC and its target gene HES1 correlates with that of the proliferative marker Ki67 in a small cohort of primary PAX-FOXO1 alveolar RMS samples. These results strongly suggest that high levels of Notch3 activation increase the proliferative potential of RMS cells." @default.
• W1988482775 created "2016-06-24" @default.
• W1988482775 creator A5006104396 @default.
• W1988482775 creator A5007476134 @default.
• W1988482775 creator A5010669543 @default.
• W1988482775 creator A5011147399 @default.
• W1988482775 creator A5015423699 @default.
• W1988482775 creator A5022712318 @default.
• W1988482775 creator A5024989705 @default.
• W1988482775 creator A5028394850 @default.
• W1988482775 creator A5031926342 @default.
• W1988482775 creator A5040210154 @default.
• W1988482775 creator A5041301571 @default.
• W1988482775 creator A5042223478 @default.
• W1988482775 creator A5044444588 @default.
• W1988482775 creator A5045994087 @default.
• W1988482775 creator A5046152737 @default.
• W1988482775 creator A5047735457 @default.
• W1988482775 creator A5057095327 @default.
• W1988482775 creator A5061528297 @default.
• W1988482775 creator A5075951287 @default.
• W1988482775 creator A5083828029 @default.
• W1988482775 creator A5091435529 @default.
• W1988482775 creator A5000732457 @default.
• W1988482775 creator A5076595938 @default.
• W1988482775 date "2014-05-05" @default.
• W1988482775 modified "2023-10-14" @default.
• W1988482775 title "Hyper-Activation of Notch3 Amplifies the Proliferative Potential of Rhabdomyosarcoma Cells" @default.
• W1988482775 cites W1542949307 @default.
• W1988482775 cites W1973569665 @default.
• W1988482775 cites W1983029447 @default.
• W1988482775 cites W1988185134 @default.
• W1988482775 cites W2000589976 @default.
• W1988482775 cites W2005787306 @default.
• W1988482775 cites W2008351799 @default.
• W1988482775 cites W2018341322 @default.
• W1988482775 cites W2021140489 @default.
• W1988482775 cites W2025611203 @default.
• W1988482775 cites W2040680836 @default.
• W1988482775 cites W2045826462 @default.
• W1988482775 cites W2047649751 @default.
• W1988482775 cites W2050499746 @default.
• W1988482775 cites W2058734213 @default.
• W1988482775 cites W2087554245 @default.
• W1988482775 cites W2087871321 @default.
• W1988482775 cites W2093355627 @default.
• W1988482775 cites W2103077999 @default.
• W1988482775 cites W2106393512 @default.
• W1988482775 cites W2112060629 @default.
• W1988482775 cites W2116965161 @default.
• W1988482775 cites W2117098558 @default.
• W1988482775 cites W2117332077 @default.
• W1988482775 cites W2117915749 @default.
• W1988482775 cites W2119501563 @default.
• W1988482775 cites W2124323423 @default.
• W1988482775 cites W2129784389 @default.
• W1988482775 cites W2133660369 @default.
• W1988482775 cites W2133906003 @default.
• W1988482775 cites W2136180038 @default.
• W1988482775 cites W2137480884 @default.
• W1988482775 cites W2147190181 @default.
• W1988482775 cites W2152880836 @default.
• W1988482775 cites W2154861644 @default.
• W1988482775 cites W2162116951 @default.
• W1988482775 cites W2163748946 @default.
• W1988482775 cites W2170400030 @default.
• W1988482775 cites W2178572083 @default.
• W1988482775 doi "https://doi.org/10.1371/journal.pone.0096238" @default.
• W1988482775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4010457" @default.
• W1988482775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24797362" @default.
• W1988482775 hasPublicationYear "2014" @default.
• W1988482775 type Work @default.
• W1988482775 sameAs 1988482775 @default.
• W1988482775 citedByCount "11" @default.
• W1988482775 countsByYear W19884827752015 @default.
• W1988482775 countsByYear W19884827752016 @default.
• W1988482775 countsByYear W19884827752017 @default.
• W1988482775 countsByYear W19884827752018 @default.
• W1988482775 countsByYear W19884827752019 @default.
• W1988482775 countsByYear W19884827752020 @default.
• W1988482775 countsByYear W19884827752022 @default.
• W1988482775 crossrefType "journal-article" @default.
• W1988482775 hasAuthorship W1988482775A5000732457 @default.
• W1988482775 hasAuthorship W1988482775A5006104396 @default.
• W1988482775 hasAuthorship W1988482775A5007476134 @default.
• W1988482775 hasAuthorship W1988482775A5010669543 @default.
• W1988482775 hasAuthorship W1988482775A5011147399 @default.
• W1988482775 hasAuthorship W1988482775A5015423699 @default.
• W1988482775 hasAuthorship W1988482775A5022712318 @default.
• W1988482775 hasAuthorship W1988482775A5024989705 @default.
• W1988482775 hasAuthorship W1988482775A5028394850 @default.
• W1988482775 hasAuthorship W1988482775A5031926342 @default.
• W1988482775 hasAuthorship W1988482775A5040210154 @default.
• W1988482775 hasAuthorship W1988482775A5041301571 @default.
• W1988482775 hasAuthorship W1988482775A5042223478 @default.
• W1988482775 hasAuthorship W1988482775A5044444588 @default.
• W1988482775 hasAuthorship W1988482775A5045994087 @default.
• W1988482775 hasAuthorship W1988482775A5046152737 @default.

• next