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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988484759> ?p ?o ?g. }

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• W1988484759 abstract "Carcinogenesis data for 315 chemicals were obtained from the National Cancer Institute-National Toxicology Program (NCI-NTP) bioassay programs and were analyzed to examine the shape of carcinogenesis dose-response curves. Tumor site data were more often consistent with a quadratic response than with a linear response, suggesting that the routine use of linear dose-response models will often overestimate risk. Information from in vivo short-term mutagenicity and genotoxicity assays was also obtained for most of these rodent bioassays. It was found that there were no clear relationships between the shape of the carcinogenesis dose-response curve and the result of the short-term test. These observations argue against the concept that carcinogens that are positive in a short-term assay be regulated using a linear dose-response curve and those that are negative be regulated using a sublinear dose-response curve or a safety factor approach." @default.
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• W1988484759 date "1994-01-01" @default.
• W1988484759 modified "2023-09-28" @default.
• W1988484759 title "Nonlinearity of dose-response functions for carcinogenicity." @default.
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• W1988484759 doi "https://doi.org/10.1289/ehp.94102s1109" @default.
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