Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988489044> ?p ?o ?g. }
- W1988489044 endingPage "374" @default.
- W1988489044 startingPage "365" @default.
- W1988489044 abstract "The development of tolerance to the analgesic effects of morphine as well as morphine dependence were greatly reduced by co-administration with morphine of GM1 ganglioside, a substance reported to block the translocation of protein kinase C (PKC) from cytosol to membrane of neurons. Rats made tolerant to intrathecal administration of morphine showed increased membrane-bound PKC in the superficial layers (laminae I and II) of the spinal cord dorsal horn but not in deeper layers. This increase was prevented by co-administration with morphine of GM1 ganglioside. These results indicate that the translocation and activation of PKC may be a critical step in the development of opiate tolerance and dependence. Modulation of PKC translocation and activation may prove useful for the management of pain and opiate addiction." @default.
- W1988489044 created "2016-06-24" @default.
- W1988489044 creator A5030438559 @default.
- W1988489044 creator A5081960363 @default.
- W1988489044 creator A5088028504 @default.
- W1988489044 date "1995-06-01" @default.
- W1988489044 modified "2023-10-14" @default.
- W1988489044 title "The development of morphine tolerance and dependence is associated with translocation of protein kinase C" @default.
- W1988489044 cites W1490844487 @default.
- W1988489044 cites W1598278338 @default.
- W1988489044 cites W1851460426 @default.
- W1988489044 cites W1980356075 @default.
- W1988489044 cites W1985413716 @default.
- W1988489044 cites W1991209873 @default.
- W1988489044 cites W2007263885 @default.
- W1988489044 cites W2007289876 @default.
- W1988489044 cites W2009858032 @default.
- W1988489044 cites W2012008365 @default.
- W1988489044 cites W2016018088 @default.
- W1988489044 cites W2027879757 @default.
- W1988489044 cites W2033415985 @default.
- W1988489044 cites W2033525233 @default.
- W1988489044 cites W2036507634 @default.
- W1988489044 cites W2041718289 @default.
- W1988489044 cites W2045798386 @default.
- W1988489044 cites W2048712968 @default.
- W1988489044 cites W2050710574 @default.
- W1988489044 cites W2054308052 @default.
- W1988489044 cites W2055233235 @default.
- W1988489044 cites W2061152669 @default.
- W1988489044 cites W2070765568 @default.
- W1988489044 cites W2077348695 @default.
- W1988489044 cites W2085711502 @default.
- W1988489044 cites W2085909636 @default.
- W1988489044 cites W2088103235 @default.
- W1988489044 cites W2111062311 @default.
- W1988489044 cites W2113306289 @default.
- W1988489044 cites W2135389271 @default.
- W1988489044 cites W2143046795 @default.
- W1988489044 cites W2147107991 @default.
- W1988489044 cites W2156989493 @default.
- W1988489044 cites W2159422646 @default.
- W1988489044 cites W2165801675 @default.
- W1988489044 cites W4319688303 @default.
- W1988489044 doi "https://doi.org/10.1016/0304-3959(95)00023-l" @default.
- W1988489044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7478679" @default.
- W1988489044 hasPublicationYear "1995" @default.
- W1988489044 type Work @default.
- W1988489044 sameAs 1988489044 @default.
- W1988489044 citedByCount "201" @default.
- W1988489044 countsByYear W19884890442012 @default.
- W1988489044 countsByYear W19884890442013 @default.
- W1988489044 countsByYear W19884890442014 @default.
- W1988489044 countsByYear W19884890442015 @default.
- W1988489044 countsByYear W19884890442016 @default.
- W1988489044 countsByYear W19884890442017 @default.
- W1988489044 countsByYear W19884890442018 @default.
- W1988489044 countsByYear W19884890442019 @default.
- W1988489044 countsByYear W19884890442021 @default.
- W1988489044 countsByYear W19884890442022 @default.
- W1988489044 countsByYear W19884890442023 @default.
- W1988489044 crossrefType "journal-article" @default.
- W1988489044 hasAuthorship W1988489044A5030438559 @default.
- W1988489044 hasAuthorship W1988489044A5081960363 @default.
- W1988489044 hasAuthorship W1988489044A5088028504 @default.
- W1988489044 hasConcept C104317684 @default.
- W1988489044 hasConcept C126322002 @default.
- W1988489044 hasConcept C138626823 @default.
- W1988489044 hasConcept C169760540 @default.
- W1988489044 hasConcept C170493617 @default.
- W1988489044 hasConcept C181199279 @default.
- W1988489044 hasConcept C184235292 @default.
- W1988489044 hasConcept C185592680 @default.
- W1988489044 hasConcept C195794163 @default.
- W1988489044 hasConcept C2777331542 @default.
- W1988489044 hasConcept C2777389121 @default.
- W1988489044 hasConcept C2778140631 @default.
- W1988489044 hasConcept C2778750930 @default.
- W1988489044 hasConcept C2780775167 @default.
- W1988489044 hasConcept C2780820201 @default.
- W1988489044 hasConcept C2781063702 @default.
- W1988489044 hasConcept C55493867 @default.
- W1988489044 hasConcept C71924100 @default.
- W1988489044 hasConcept C86803240 @default.
- W1988489044 hasConcept C98274493 @default.
- W1988489044 hasConcept C98539663 @default.
- W1988489044 hasConceptScore W1988489044C104317684 @default.
- W1988489044 hasConceptScore W1988489044C126322002 @default.
- W1988489044 hasConceptScore W1988489044C138626823 @default.
- W1988489044 hasConceptScore W1988489044C169760540 @default.
- W1988489044 hasConceptScore W1988489044C170493617 @default.
- W1988489044 hasConceptScore W1988489044C181199279 @default.
- W1988489044 hasConceptScore W1988489044C184235292 @default.
- W1988489044 hasConceptScore W1988489044C185592680 @default.
- W1988489044 hasConceptScore W1988489044C195794163 @default.
- W1988489044 hasConceptScore W1988489044C2777331542 @default.
- W1988489044 hasConceptScore W1988489044C2777389121 @default.
- W1988489044 hasConceptScore W1988489044C2778140631 @default.