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• W1988491330 endingPage "436" @default.
• W1988491330 startingPage "430" @default.
• W1988491330 abstract "Neboglamine is a functional modulator of the glycine site on the N-methyl-d-aspartate (NMDA) receptor. Dysfunction of this receptor has been associated with negative and cognitive symptoms in schizophrenia. Thus, we tested the hypothesis that neboglamine behaves as a potential antipsychotic. We compared the effects of neboglamine, d-serine, clozapine, and haloperidol on the expression of Fos-like immunoreactivity (FLI), a marker of neuronal activation, in rat forebrain. We also studied the effects of these agents on phencyclidine (PCP)-induced behaviour in rats, a model predictive of potential antipsychotic activity. Neboglamine, like haloperidol and clozapine, significantly increased the number of FLI-positive cells in the prefrontal cortex, nucleus accumbens, and lateral septal nucleus (3.2-, 4.8-, and 4.5-fold over control, respectively). Haloperidol dramatically increased FLI (390-fold over control) in the dorsolateral striatum, a brain region in which neboglamine and clozapine had no effect. The pattern of FLI induced by neboglamine closely matched that of d-serine, an endogenous agonist at the glycine site of NMDA receptors. Consistent with this finding, neboglamine restored NMDA-mediated neurotransmitter release in frontal cortex punches exposed to the NMDA antagonist PCP. In the behavioural model, all test compounds significantly inhibited PCP-induced hyperlocomotion. Unlike haloperidol and clozapine, neither neboglamine nor d-serine affected the basal levels of locomotor activity. Moreover, oral neboglamine dose-dependently inhibited both the hyperlocomotion and the frequency of rearing behaviour induced by PCP. These results, while confirming that the NMDA glycine site is a feasible target for activating the frontostriatal system, support the clinical evaluation of neboglamine as a treatment for schizophrenia." @default.
• W1988491330 created "2016-06-24" @default.
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• W1988491330 date "2010-05-01" @default.
• W1988491330 modified "2023-10-17" @default.
• W1988491330 title "Antipsychotic-like effects of the N-methyl-d-aspartate receptor modulator neboglamine: An immunohistochemical and behavioural study in the rat" @default.
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• W1988491330 doi "https://doi.org/10.1016/j.phrs.2009.12.010" @default.
• W1988491330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20045056" @default.
• W1988491330 hasPublicationYear "2010" @default.
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