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• W1988492168 abstract "The function of His118 in elongation factor (EF)-Tu from Escherichia coli was investigated by its substitution with glycine. The substitution had a differential effect on individual functions of the protein. The affinity for aminoacyl (aa)-tRNA and the intrinsic GTPase activity of the mutant EF-Tu were decreased whereas the response of its GTPase center to aa-tRNA was strongly increased. These results suggest that the region around His118 is involved in the binding of aa-tRNA and in the transmission of a turn-off signal generated by the interaction with aa-tRNA and directed to the GTPase center of EF-Tu." @default.
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• W1988492168 date "1994-04-18" @default.
• W1988492168 modified "2023-09-30" @default.
• W1988492168 title "Histidine-118 of elongation factor Tu: its role in aminoacyl-tRNA binding and regulation of the GTPase activity" @default.
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• W1988492168 doi "https://doi.org/10.1016/0014-5793(94)80614-4" @default.
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