FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988496487> ?p ?o ?g. }

• W1988496487 endingPage "631" @default.
• W1988496487 startingPage "623" @default.
• W1988496487 abstract "The low viability of embryos reconstructed by somatic cell nuclear transfer (SCNT) is believed to be associated with epigenetic modification errors, and reduction of those errors may improve the viability of SCNT embryos. The present study shows the effect of trichostatin A (TSA), a strong inhibitor of histone deacetylase, on the development of murine SCNT embryos. After enucleation and nuclear injection, reconstructed murine oocytes were activated with or without TSA for 6 hr (TSA-6 hr). After activation, TSA treatment was extended to 3 hr (TSA-9 hr), 5 hr (TSA-11 hr) and 18 hr (TSA-24 hr) during culture. As a result, the SCNT embryos in the TSA-11 hr group showed a remarkably higher blastocyst rate (21.1%) when compared with the nontreated embryos (3.4%), while the concentration of TSA did not significantly affect embryonic development. The expressions of histone deacetylase (HDAC1 and HDAC2) and DNA methylation (DNMT3a and DNMT3b) genes decreased in the TSA-11 hr and TSA-24 hr groups, while there was an increase in the expression of histone acetyltransferase (P300 and CBP), pluripotency (OCT4 and NANOG) and embryonic growth/trophectoderm formation (FGF4)-related genes in the same groups. The expression of CDX2, a critical gene for trophectoderm formation was upregulated only in the TSA-24 hr group. Our results show that TSA treatment during the peri- and postactivation period improves the development of reconstructed murine embryos, and this observation may be explained by enhanced epigenetic modification of somatic cells caused by TSA-induced hyperacetylation, demethylation and upregulation of pluripotency and embryonic growth after SCNT." @default.
• W1988496487 created "2016-06-24" @default.
• W1988496487 creator A5037168895 @default.
• W1988496487 creator A5056745220 @default.
• W1988496487 date "2011-01-01" @default.
• W1988496487 modified "2023-09-26" @default.
• W1988496487 title "Extended Exposure to Trichostatin A after Activation Alters the Expression of Genes Important for Early Development in Nuclear Transfer Murine Embryos" @default.
• W1988496487 cites W1487014009 @default.
• W1988496487 cites W1497453049 @default.
• W1988496487 cites W1588697423 @default.
• W1988496487 cites W1883905837 @default.
• W1988496487 cites W1970482334 @default.
• W1988496487 cites W1973362682 @default.
• W1988496487 cites W1973959597 @default.
• W1988496487 cites W1975751233 @default.
• W1988496487 cites W1977050778 @default.
• W1988496487 cites W1979055428 @default.
• W1988496487 cites W1982533604 @default.
• W1988496487 cites W1992525863 @default.
• W1988496487 cites W1993353173 @default.
• W1988496487 cites W1994144105 @default.
• W1988496487 cites W1996103159 @default.
• W1988496487 cites W2003336531 @default.
• W1988496487 cites W2010765881 @default.
• W1988496487 cites W2011335353 @default.
• W1988496487 cites W2012206386 @default.
• W1988496487 cites W2023044209 @default.
• W1988496487 cites W2025372968 @default.
• W1988496487 cites W2032626893 @default.
• W1988496487 cites W2033110292 @default.
• W1988496487 cites W2033767072 @default.
• W1988496487 cites W2033884991 @default.
• W1988496487 cites W2040566490 @default.
• W1988496487 cites W2046028823 @default.
• W1988496487 cites W2057430589 @default.
• W1988496487 cites W2061184843 @default.
• W1988496487 cites W2062809474 @default.
• W1988496487 cites W2071953998 @default.
• W1988496487 cites W2078826636 @default.
• W1988496487 cites W2091236246 @default.
• W1988496487 cites W2093155802 @default.
• W1988496487 cites W2098066278 @default.
• W1988496487 cites W2102098569 @default.
• W1988496487 cites W2106844301 @default.
• W1988496487 cites W2107257929 @default.
• W1988496487 cites W2107385641 @default.
• W1988496487 cites W2113022171 @default.
• W1988496487 cites W2113747476 @default.
• W1988496487 cites W2118582028 @default.
• W1988496487 cites W2119360718 @default.
• W1988496487 cites W2119429923 @default.
• W1988496487 cites W2121868936 @default.
• W1988496487 cites W2123829995 @default.
• W1988496487 cites W2125987139 @default.
• W1988496487 cites W2156229080 @default.
• W1988496487 cites W2160810018 @default.
• W1988496487 cites W2162438863 @default.
• W1988496487 cites W2163288644 @default.
• W1988496487 cites W2166091854 @default.
• W1988496487 cites W2182683183 @default.
• W1988496487 cites W2270546804 @default.
• W1988496487 cites W2022044834 @default.
• W1988496487 doi "https://doi.org/10.1292/jvms.10-0492" @default.
• W1988496487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21187677" @default.
• W1988496487 hasPublicationYear "2011" @default.
• W1988496487 type Work @default.
• W1988496487 sameAs 1988496487 @default.
• W1988496487 citedByCount "11" @default.
• W1988496487 countsByYear W19884964872012 @default.
• W1988496487 countsByYear W19884964872015 @default.
• W1988496487 countsByYear W19884964872018 @default.
• W1988496487 countsByYear W19884964872019 @default.
• W1988496487 countsByYear W19884964872021 @default.
• W1988496487 crossrefType "journal-article" @default.
• W1988496487 hasAuthorship W1988496487A5037168895 @default.
• W1988496487 hasAuthorship W1988496487A5056745220 @default.
• W1988496487 hasBestOaLocation W19884964871 @default.
• W1988496487 hasConcept C104317684 @default.
• W1988496487 hasConcept C107459253 @default.
• W1988496487 hasConcept C145103041 @default.
• W1988496487 hasConcept C153911025 @default.
• W1988496487 hasConcept C16685009 @default.
• W1988496487 hasConcept C185592680 @default.
• W1988496487 hasConcept C196843134 @default.
• W1988496487 hasConcept C202438428 @default.
• W1988496487 hasConcept C207701140 @default.
• W1988496487 hasConcept C2776202225 @default.
• W1988496487 hasConcept C2777865847 @default.
• W1988496487 hasConcept C2778177303 @default.
• W1988496487 hasConcept C2778305200 @default.
• W1988496487 hasConcept C41091548 @default.
• W1988496487 hasConcept C54355233 @default.
• W1988496487 hasConcept C64927066 @default.
• W1988496487 hasConcept C71924100 @default.
• W1988496487 hasConcept C86803240 @default.
• W1988496487 hasConcept C87073359 @default.
• W1988496487 hasConcept C95444343 @default.
• W1988496487 hasConceptScore W1988496487C104317684 @default.

• next