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- W1988503886 abstract "RNA editing in trypanosomatids is catalyzed by a high molecular mass RNP complex, which is only partially characterized. TbMP42 is a 42 kDa protein of unknown function that copurifies with the editing complex. The polypeptide is characterized by two Zn fingers and a potential barrel structure/OB-fold at its C terminus. Using recombinant TbMP42, we show that the protein can bind to dsRNA and dsDNA but fails to recognize DNA/RNA hybrids. rTbMP42 degrades ssRNA by a 3′ to 5′ exoribonuclease activity. In addition, rTbMP42 has endoribonuclease activity, which preferentially hydrolyzes non-base-paired uridylate-containing sequences. Gene silencing of TbMP42 inhibits cell growth and is ultimately lethal to the parasite. Mitochondrial extracts from TbMP42-minus trypanosomes have only residual RNA editing activity and strongly reduced endo-exoribonuclease activity. However, all three activities can be restored by the addition of rTbMP42. Together, the data suggest that TbMP42 contributes both endo- and exoribonuclease activity to the editing reaction cycle." @default.
- W1988503886 created "2016-06-24" @default.
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- W1988503886 date "2005-03-01" @default.
- W1988503886 modified "2023-10-16" @default.
- W1988503886 title "TbMP42, a Protein Component of the RNA Editing Complex in African Trypanosomes, Has Endo-Exoribonuclease Activity" @default.
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- W1988503886 doi "https://doi.org/10.1016/j.molcel.2005.01.018" @default.
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