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• W1988507518 startingPage "391" @default.
• W1988507518 abstract "Hepatocyte growth factor (HGF) inhibits acute liver injury. NK2 acts as an antagonist to HGF in vitro, but its in vivo function has reached no consensus conclusions. We have investigated in vivo effects of HGF and NK2 on CCl4-induced acute liver injury. Elevation of the serum alanine aminotransferase level and extension of centrilobular necrosis were inhibited in HGF transgenic mice but were promoted in NK2 transgenic mice. Hepatocyte proliferation after liver injury was not inhibited in NK2 transgenic mice. Thus, this study indicates that HGF inhibits liver injury, and NK2 antagonizes HGF on liver injury, however, NK2 may not antagonize HGF on hepatocyte proliferation." @default.
• W1988507518 created "2016-06-24" @default.
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• W1988507518 date "2002-11-23" @default.
• W1988507518 modified "2023-09-24" @default.
• W1988507518 title "CCl₄-induced acute liver injury in mice is inhibited by hepatocyte growth factor overexpression but stimulated by NK2 overexpression" @default.
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• W1988507518 doi "https://doi.org/10.1016/s0014-5793(02)03714-6" @default.
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