FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988508746> ?p ?o ?g. }

• W1988508746 endingPage "154" @default.
• W1988508746 startingPage "145" @default.
• W1988508746 abstract "Cone snails (Conus sp.) are poisonous animals that can be found in all oceans where they developed a venomous strategy to prey or to defend. The venom of these species contains an undeniable source of unique and potent pharmacologically active compounds. Their peptide compounds, called conotoxins, are not only interesting for the development of new pharmaceutical ligands, but they are also useful for studying their broad spectrum of targets. One conotoxin family in particular, the α-conotoxins, acts on nicotinic acetylcholine receptors (nAChRs) which dysfunctions play important roles in pathologies such as epilepsy, myasthenic syndromes, schizophrenia, Parkinson's disease and Alzheimer's disease. Here we define a new subclass of the α-conotoxin family. We purified the venom of a yet unexplored cone snail species, i.e. Conus australis, and we isolated a 16-amino acid peptide named α-conotoxin AusIA. The peptide has the typical α-conotoxin CC-Xm-C-Xn-C framework, but both loops (m/n) contain 5 amino acids, which has never been described before. Using conventional electrophysiology we investigated the response of synthetically made globular (I–III, II–IV) and ribbon (I–IV, II–III) AusIA to different nicotinic acetylcholine receptors. The α7 nAChR was the only receptor found to be blocked with a similar potency by both peptide-configurations. This suggests that both α5/5 conotoxin isomers might be present in the venom gland of C. australis. NMR spectroscopy showed that no secondary structures define the peptides' three-dimensional topology. Moreover, the ribbon configuration, which is generally considered to be non-native, is more stable than the globular isomer. Accordingly, our findings show relevancy concerning the α-conotoxin classification which might be helpful in the design of novel therapeutic compounds." @default.
• W1988508746 created "2016-06-24" @default.
• W1988508746 creator A5009712758 @default.
• W1988508746 creator A5020989565 @default.
• W1988508746 creator A5021345022 @default.
• W1988508746 creator A5032577144 @default.
• W1988508746 creator A5051638010 @default.
• W1988508746 creator A5056532493 @default.
• W1988508746 creator A5062031834 @default.
• W1988508746 creator A5063779098 @default.
• W1988508746 creator A5064158383 @default.
• W1988508746 creator A5078010584 @default.
• W1988508746 creator A5089787128 @default.
• W1988508746 date "2014-12-01" @default.
• W1988508746 modified "2023-10-18" @default.
• W1988508746 title "Discovery of a new subclass of α-conotoxins in the venom of Conus australis" @default.
• W1988508746 cites W1525265122 @default.
• W1988508746 cites W1560891849 @default.
• W1988508746 cites W1599390971 @default.
• W1988508746 cites W1637250296 @default.
• W1988508746 cites W1971009901 @default.
• W1988508746 cites W1999337430 @default.
• W1988508746 cites W2003630255 @default.
• W1988508746 cites W2004762914 @default.
• W1988508746 cites W2009809547 @default.
• W1988508746 cites W2014591547 @default.
• W1988508746 cites W2021667046 @default.
• W1988508746 cites W2022181012 @default.
• W1988508746 cites W2023259110 @default.
• W1988508746 cites W2028238530 @default.
• W1988508746 cites W2028723154 @default.
• W1988508746 cites W2032529224 @default.
• W1988508746 cites W2040945433 @default.
• W1988508746 cites W2041786343 @default.
• W1988508746 cites W2052956415 @default.
• W1988508746 cites W2053846150 @default.
• W1988508746 cites W2053870022 @default.
• W1988508746 cites W2054030400 @default.
• W1988508746 cites W2056045202 @default.
• W1988508746 cites W2059235702 @default.
• W1988508746 cites W2060488758 @default.
• W1988508746 cites W2062473403 @default.
• W1988508746 cites W2068450558 @default.
• W1988508746 cites W2069788048 @default.
• W1988508746 cites W2076755375 @default.
• W1988508746 cites W2084971410 @default.
• W1988508746 cites W2085405019 @default.
• W1988508746 cites W2086647236 @default.
• W1988508746 cites W2103229353 @default.
• W1988508746 cites W2104838343 @default.
• W1988508746 cites W2106449364 @default.
• W1988508746 cites W2110196922 @default.
• W1988508746 cites W2111723220 @default.
• W1988508746 cites W2128043404 @default.
• W1988508746 cites W2134571618 @default.
• W1988508746 cites W2139053364 @default.
• W1988508746 cites W2139437087 @default.
• W1988508746 cites W2139835922 @default.
• W1988508746 cites W2148677994 @default.
• W1988508746 cites W2151663467 @default.
• W1988508746 cites W2152418590 @default.
• W1988508746 cites W2155687897 @default.
• W1988508746 cites W2160386479 @default.
• W1988508746 cites W2161684706 @default.
• W1988508746 cites W2163545771 @default.
• W1988508746 cites W2292780216 @default.
• W1988508746 cites W4319292982 @default.
• W1988508746 doi "https://doi.org/10.1016/j.toxicon.2014.08.074" @default.
• W1988508746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25194747" @default.
• W1988508746 hasPublicationYear "2014" @default.
• W1988508746 type Work @default.
• W1988508746 sameAs 1988508746 @default.
• W1988508746 citedByCount "24" @default.
• W1988508746 countsByYear W19885087462015 @default.
• W1988508746 countsByYear W19885087462016 @default.
• W1988508746 countsByYear W19885087462018 @default.
• W1988508746 countsByYear W19885087462019 @default.
• W1988508746 countsByYear W19885087462020 @default.
• W1988508746 countsByYear W19885087462021 @default.
• W1988508746 countsByYear W19885087462022 @default.
• W1988508746 countsByYear W19885087462023 @default.
• W1988508746 crossrefType "journal-article" @default.
• W1988508746 hasAuthorship W1988508746A5009712758 @default.
• W1988508746 hasAuthorship W1988508746A5020989565 @default.
• W1988508746 hasAuthorship W1988508746A5021345022 @default.
• W1988508746 hasAuthorship W1988508746A5032577144 @default.
• W1988508746 hasAuthorship W1988508746A5051638010 @default.
• W1988508746 hasAuthorship W1988508746A5056532493 @default.
• W1988508746 hasAuthorship W1988508746A5062031834 @default.
• W1988508746 hasAuthorship W1988508746A5063779098 @default.
• W1988508746 hasAuthorship W1988508746A5064158383 @default.
• W1988508746 hasAuthorship W1988508746A5078010584 @default.
• W1988508746 hasAuthorship W1988508746A5089787128 @default.
• W1988508746 hasConcept C105702510 @default.
• W1988508746 hasConcept C170493617 @default.
• W1988508746 hasConcept C175234850 @default.
• W1988508746 hasConcept C185592680 @default.
• W1988508746 hasConcept C188987157 @default.

• next