FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988524207> ?p ?o ?g. }

• W1988524207 endingPage "799" @default.
• W1988524207 startingPage "788" @default.
• W1988524207 abstract "Early-stage evolutionary development of the universal genetic code remains a fundamental, open problem. One of the possible scenarios suggests that the code evolved in response to direct interactions between peptides and RNA oligonucleotides in the primordial environment. Recently, we have revealed a strong matching between base-binding preferences of modern protein sequences and the composition of their cognate mRNA coding sequences. These results point directly at the physicochemical foundation behind the code’s origin, but also support the possibility of direct complementary interactions between proteins and their cognate mRNAs, especially if the two are unstructured. Here, we analyze molecular-surface mapping of knowledge-based amino-acid/nucleobase interaction preferences for a set of complete, high-resolution protein structures and show that the connection between the two biopolymers could remain relevant even for structured, folded proteins. Specifically, protein surface loops are strongly enriched in residues with a high binding propensity for guanine and cytosine, while adenine- and uracil-preferring residues are uniformly distributed throughout protein structures. Moreover, compositional complementarity of cognate protein and mRNA sequences remains strong even after weighting protein sequence profiles by residue solvent exposure. Our results support the possibility that protein/mRNA sequence complementarity may also translate to cognate interactions between structured biopolymers." @default.
• W1988524207 created "2016-06-24" @default.
• W1988524207 creator A5018907948 @default.
• W1988524207 creator A5083503483 @default.
• W1988524207 creator A5089609962 @default.
• W1988524207 date "2014-11-21" @default.
• W1988524207 modified "2023-09-25" @default.
• W1988524207 title "On the Contribution of Protein Spatial Organization to the Physicochemical Interconnection between Proteins and Their Cognate mRNAs" @default.
• W1988524207 cites W1963573192 @default.
• W1988524207 cites W1966429662 @default.
• W1988524207 cites W1977168683 @default.
• W1988524207 cites W1978595049 @default.
• W1988524207 cites W1980462851 @default.
• W1988524207 cites W1985924595 @default.
• W1988524207 cites W1986911150 @default.
• W1988524207 cites W1989497627 @default.
• W1988524207 cites W1995143868 @default.
• W1988524207 cites W2004464056 @default.
• W1988524207 cites W2011256757 @default.
• W1988524207 cites W2013354180 @default.
• W1988524207 cites W2027914283 @default.
• W1988524207 cites W2041440237 @default.
• W1988524207 cites W2048039699 @default.
• W1988524207 cites W2072391778 @default.
• W1988524207 cites W2076091642 @default.
• W1988524207 cites W2083408202 @default.
• W1988524207 cites W2083627310 @default.
• W1988524207 cites W2085560535 @default.
• W1988524207 cites W2100681850 @default.
• W1988524207 cites W2127982146 @default.
• W1988524207 cites W2137913279 @default.
• W1988524207 cites W2153091138 @default.
• W1988524207 cites W2155933192 @default.
• W1988524207 cites W2159249646 @default.
• W1988524207 cites W2163702806 @default.
• W1988524207 cites W2168276925 @default.
• W1988524207 cites W3191945407 @default.
• W1988524207 doi "https://doi.org/10.3390/life4040788" @default.
• W1988524207 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4284467" @default.
• W1988524207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25423140" @default.
• W1988524207 hasPublicationYear "2014" @default.
• W1988524207 type Work @default.
• W1988524207 sameAs 1988524207 @default.
• W1988524207 citedByCount "7" @default.
• W1988524207 countsByYear W19885242072015 @default.
• W1988524207 countsByYear W19885242072017 @default.
• W1988524207 countsByYear W19885242072018 @default.
• W1988524207 countsByYear W19885242072020 @default.
• W1988524207 countsByYear W19885242072022 @default.
• W1988524207 countsByYear W19885242072023 @default.
• W1988524207 crossrefType "journal-article" @default.
• W1988524207 hasAuthorship W1988524207A5018907948 @default.
• W1988524207 hasAuthorship W1988524207A5083503483 @default.
• W1988524207 hasAuthorship W1988524207A5089609962 @default.
• W1988524207 hasBestOaLocation W19885242071 @default.
• W1988524207 hasConcept C104317684 @default.
• W1988524207 hasConcept C10853874 @default.
• W1988524207 hasConcept C138885662 @default.
• W1988524207 hasConcept C2776023528 @default.
• W1988524207 hasConcept C2777392089 @default.
• W1988524207 hasConcept C2779554091 @default.
• W1988524207 hasConcept C41895202 @default.
• W1988524207 hasConcept C54355233 @default.
• W1988524207 hasConcept C552990157 @default.
• W1988524207 hasConcept C55493867 @default.
• W1988524207 hasConcept C61234307 @default.
• W1988524207 hasConcept C67705224 @default.
• W1988524207 hasConcept C70721500 @default.
• W1988524207 hasConcept C86803240 @default.
• W1988524207 hasConcept C91779695 @default.
• W1988524207 hasConceptScore W1988524207C104317684 @default.
• W1988524207 hasConceptScore W1988524207C10853874 @default.
• W1988524207 hasConceptScore W1988524207C138885662 @default.
• W1988524207 hasConceptScore W1988524207C2776023528 @default.
• W1988524207 hasConceptScore W1988524207C2777392089 @default.
• W1988524207 hasConceptScore W1988524207C2779554091 @default.
• W1988524207 hasConceptScore W1988524207C41895202 @default.
• W1988524207 hasConceptScore W1988524207C54355233 @default.
• W1988524207 hasConceptScore W1988524207C552990157 @default.
• W1988524207 hasConceptScore W1988524207C55493867 @default.
• W1988524207 hasConceptScore W1988524207C61234307 @default.
• W1988524207 hasConceptScore W1988524207C67705224 @default.
• W1988524207 hasConceptScore W1988524207C70721500 @default.
• W1988524207 hasConceptScore W1988524207C86803240 @default.
• W1988524207 hasConceptScore W1988524207C91779695 @default.
• W1988524207 hasIssue "4" @default.
• W1988524207 hasLocation W19885242071 @default.
• W1988524207 hasLocation W19885242072 @default.
• W1988524207 hasLocation W19885242073 @default.
• W1988524207 hasLocation W19885242074 @default.
• W1988524207 hasLocation W19885242075 @default.
• W1988524207 hasLocation W19885242076 @default.
• W1988524207 hasOpenAccess W1988524207 @default.
• W1988524207 hasPrimaryLocation W19885242071 @default.
• W1988524207 hasRelatedWork W1970912387 @default.
• W1988524207 hasRelatedWork W1980400961 @default.
• W1988524207 hasRelatedWork W1981808967 @default.
• W1988524207 hasRelatedWork W1985445036 @default.

• next