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- W1988531768 abstract "1,2- and 1,3-glyceryl dinitrates (1,2-GDN and 1,3-GDN) are the primary metabolites of glyceryl trinitrate, a commonly used anti-anginal agent. The goal of this study was to examine the pharmacokinetic properties of these metabolites in rats. Sprague-Dawley rats were infused intravenously with 0·25 or 2·0 μgmin−1 of either 1,2- or 1,3-GDN for 70 min, during which steady state blood concentrations were achieved. Post-infusion blood samples were collected for 30 min. 1,2-GDN was found to possess slightly higher clearance (32·3 vs 21·8 ml min−1 kg−1) and volume of distribution (695 vs 454 ml kg−1) than 1,3-GDN; however, the two metabolites exhibited similar mean residence times (22·0 vs 21·8 min). Upon an 8-fold increase in the infusion rate, the pharmacokinetic parameters were not significantly altered for either 1,2- or 1,3-GDN. When each GDN was co-infused with an 8-fold higher dose of the other GDN, there were also no significant changes in the parameters." @default.
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- W1988531768 date "1991-04-01" @default.
- W1988531768 modified "2023-09-26" @default.
- W1988531768 title "Pharmacokinetic studies of the nitroglycerin metabolites, 1,2- and 1,3- glyceryl dinitrates, in the rat" @default.
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- W1988531768 doi "https://doi.org/10.1002/bdd.2510120306" @default.
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