Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988551135> ?p ?o ?g. }
- W1988551135 endingPage "702" @default.
- W1988551135 startingPage "698" @default.
- W1988551135 abstract "Drusen, the pathognomonic lesion of age-related macular degeneration, are dynamic and undergo both growth and regression. Using histochemistry to localise esterified cholesterol (EC), we investigated small drusen to discover signs of dynamism.Flat mounts of Bruch's membrane were prepared from peripheral retinas of six donor eyes without chorioretinal pathology that were preserved within 6 h of death. Tissues were pretreated with ethanol to extract native unesterified cholesterol, incubated with cholesterol esterase and stained with filipin to bind unesterified cholesterol that was newly released by hydrolysis. Tissues were imaged with wide-field epifluorescence microscopy. Diameters were measured and internal substructures (shells, lakes) assessed using previous descriptors.Of 676 drusen with mean diameter of 26.87 µm, 41.6% were stained homogeneously and 45.7% had lakes of pooled EC. Clusters of 2-7 drusen with similar staining patterns accounted for 25.3% of drusen. Increased EC content near the druse rim (shells) occurred in 10.5%.Over half of very small drusen at the edge of clinical detectability have evidence for internal remodelling, suggesting that both formative and removal events are present early in the druse lifecycle." @default.
- W1988551135 created "2016-06-24" @default.
- W1988551135 creator A5005513224 @default.
- W1988551135 creator A5020684039 @default.
- W1988551135 creator A5065561626 @default.
- W1988551135 creator A5086273254 @default.
- W1988551135 date "2014-02-19" @default.
- W1988551135 modified "2023-09-27" @default.
- W1988551135 title "Internal structure consistent with remodelling in very small drusen, revealed by filipin histochemistry for esterified cholesterol" @default.
- W1988551135 cites W1574065611 @default.
- W1988551135 cites W1967386709 @default.
- W1988551135 cites W1967586591 @default.
- W1988551135 cites W1970714860 @default.
- W1988551135 cites W1982288647 @default.
- W1988551135 cites W1985731048 @default.
- W1988551135 cites W1993828795 @default.
- W1988551135 cites W1995693747 @default.
- W1988551135 cites W1996821302 @default.
- W1988551135 cites W2000399151 @default.
- W1988551135 cites W2001666211 @default.
- W1988551135 cites W2001720244 @default.
- W1988551135 cites W2002437061 @default.
- W1988551135 cites W2003101845 @default.
- W1988551135 cites W2004912852 @default.
- W1988551135 cites W2006242015 @default.
- W1988551135 cites W200886222 @default.
- W1988551135 cites W2009960960 @default.
- W1988551135 cites W2013969919 @default.
- W1988551135 cites W2016520383 @default.
- W1988551135 cites W2018719587 @default.
- W1988551135 cites W2020533889 @default.
- W1988551135 cites W2025251914 @default.
- W1988551135 cites W2027733533 @default.
- W1988551135 cites W2029083496 @default.
- W1988551135 cites W2031300697 @default.
- W1988551135 cites W2036977833 @default.
- W1988551135 cites W2064850090 @default.
- W1988551135 cites W2074342224 @default.
- W1988551135 cites W2075592416 @default.
- W1988551135 cites W2077366389 @default.
- W1988551135 cites W2081410115 @default.
- W1988551135 cites W2081872210 @default.
- W1988551135 cites W2094629035 @default.
- W1988551135 cites W2095623631 @default.
- W1988551135 cites W2115773920 @default.
- W1988551135 cites W2127507482 @default.
- W1988551135 cites W2130288893 @default.
- W1988551135 cites W2134616761 @default.
- W1988551135 cites W2152571689 @default.
- W1988551135 cites W2170201303 @default.
- W1988551135 doi "https://doi.org/10.1136/bjophthalmol-2013-304226" @default.
- W1988551135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24554738" @default.
- W1988551135 hasPublicationYear "2014" @default.
- W1988551135 type Work @default.
- W1988551135 sameAs 1988551135 @default.
- W1988551135 citedByCount "11" @default.
- W1988551135 countsByYear W19885511352014 @default.
- W1988551135 countsByYear W19885511352015 @default.
- W1988551135 countsByYear W19885511352017 @default.
- W1988551135 countsByYear W19885511352019 @default.
- W1988551135 countsByYear W19885511352020 @default.
- W1988551135 countsByYear W19885511352021 @default.
- W1988551135 countsByYear W19885511352022 @default.
- W1988551135 crossrefType "journal-article" @default.
- W1988551135 hasAuthorship W1988551135A5005513224 @default.
- W1988551135 hasAuthorship W1988551135A5020684039 @default.
- W1988551135 hasAuthorship W1988551135A5065561626 @default.
- W1988551135 hasAuthorship W1988551135A5086273254 @default.
- W1988551135 hasConcept C118487528 @default.
- W1988551135 hasConcept C126322002 @default.
- W1988551135 hasConcept C142724271 @default.
- W1988551135 hasConcept C204232928 @default.
- W1988551135 hasConcept C2776403814 @default.
- W1988551135 hasConcept C2778163477 @default.
- W1988551135 hasConcept C2779093074 @default.
- W1988551135 hasConcept C2779630084 @default.
- W1988551135 hasConcept C2781156865 @default.
- W1988551135 hasConcept C71924100 @default.
- W1988551135 hasConcept C74864618 @default.
- W1988551135 hasConceptScore W1988551135C118487528 @default.
- W1988551135 hasConceptScore W1988551135C126322002 @default.
- W1988551135 hasConceptScore W1988551135C142724271 @default.
- W1988551135 hasConceptScore W1988551135C204232928 @default.
- W1988551135 hasConceptScore W1988551135C2776403814 @default.
- W1988551135 hasConceptScore W1988551135C2778163477 @default.
- W1988551135 hasConceptScore W1988551135C2779093074 @default.
- W1988551135 hasConceptScore W1988551135C2779630084 @default.
- W1988551135 hasConceptScore W1988551135C2781156865 @default.
- W1988551135 hasConceptScore W1988551135C71924100 @default.
- W1988551135 hasConceptScore W1988551135C74864618 @default.
- W1988551135 hasIssue "5" @default.
- W1988551135 hasLocation W19885511351 @default.
- W1988551135 hasLocation W19885511352 @default.
- W1988551135 hasOpenAccess W1988551135 @default.
- W1988551135 hasPrimaryLocation W19885511351 @default.
- W1988551135 hasRelatedWork W2336818263 @default.
- W1988551135 hasRelatedWork W2382084362 @default.
- W1988551135 hasRelatedWork W3032635735 @default.