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- W1988551782 abstract "Little is known about the right ventricular (RV) TGFβ superfamily in human end-stage heart failure (HF). We performed RNAseq (30M target reads/cDNA library, paired-end 50 bp sequencing by Illumina HiSeq 25009) on 5 unused donor RVs (DON) and 22 explanted HF RVs. We used DESeq to detect differentially expressed genes (DEGs, adjusted p < 0.05) and Ingenuity for pathway analyses. Among TGFβ ligands, TGFβ2 and LEFTY2 were increased without changes in TGFβ1, -3, BMP 1-8, -10, -15, LEFTY1, NODAL, INHA-E, AMH or GDF3-11, -15. TGFβR2 was decreased without change in TGFβR1, -3, BMPR1A, -1B,-2 or ACVR1,-1B/C, -2A/B. BMPER was decreased and SMOC2 increased without change in CHRD, -DL1/2, TWSG1, AMN or SMOC1. No associated factors were different including SMAD 1-7, -9, LTBP1-4, MSTN, NDG, TGIF1/2, FSTIL1, -3-5, NBL1, GREM1/2, ENG, BAMBI, ENG, TDGF1, SKI, SKIL, SKIV, SMURF1/2, USP1, -4, -15, SBNO1/2, RNF111, FOXA1, EOMES, POU5F1, NANOG, MYOD1, LEF1, LIMK1, EP300, CREBBP, TCF7L2, CBX3 or SHC1. There were no changes in non-canonical factors PARD6A, -B, -G, SMURF1/2, TRAF6 or GSK3A. Predicted Smad 2/3 and 1/5/8 signaling was decreased in HF RVs (Figure, inhibition = blue). Activated upstream regulators predicted included SMAD7, α-catenin, INHA, WISP2 and laminin. Inhibited upstream regulators predicted included TGFβ1, FGF2, CTGF, FGFR2, ITGB1, IL1B and EGF. Smad 2/3 and 1/5/8 mediated TGFβ superfamily system signaling is reduced in the HF RV." @default.
- W1988551782 created "2016-06-24" @default.
- W1988551782 creator A5027291356 @default.
- W1988551782 date "2014-08-01" @default.
- W1988551782 modified "2023-10-16" @default.
- W1988551782 title "Right Ventricular TGFβ Superfamily in Human Heart Failure" @default.
- W1988551782 doi "https://doi.org/10.1016/j.cardfail.2014.06.079" @default.
- W1988551782 hasPublicationYear "2014" @default.
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