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• W1988555890 abstract "Genetic predisposition of otosclerosis has long been suspected, but unclarified. Unique coexpression pattern of measles virus receptor (CD46) splicing isoforms in the human otic capsule is assumed, since otosclerosis is a measles virus-associated organ-specific disease. In order to identify CD46 involved in the pathogenesis of otosclerosis, we used representative groups of histologically diagnosed otosclerotic, nonotosclerotic, and normal stapes footplates <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mrow><mml:mo stretchy=false>(</mml:mo><mml:mrow><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>109</mml:mn></mml:mrow><mml:mo stretchy=false>)</mml:mo></mml:mrow></mml:mrow></mml:math>. Consecutive histopathological examinations and CD46-specific Western blot analysis were performed. Normal and nonotosclerotic stapes footplates showed consistent expression of the conventional c, d, e, f , and l CD46 isoforms. In contrast, four novel isoforms (os1–4) translated as intact proteins were additionally detected in each otosclerotic specimen. The study herein presented provides evidence for the otosclerosis-associated expression pattern of CD46. This finding might explain the organ-specific, virus-associated and autoimmune-inflammatory pathogenesis of otosclerosis. Regarding our current knowledge, this is the first report that confirms the presence of four new disease-specific protein variants of CD46." @default.
• W1988555890 created "2016-06-24" @default.
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• W1988555890 date "2013-06-20" @default.
• W1988555890 modified "2023-10-18" @default.
• W1988555890 title "Detection of Otosclerosis-Specific Measles Virus Receptor (Cd46) Protein Isoforms" @default.
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• W1988555890 doi "https://doi.org/10.1155/2013/479482" @default.
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