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- W1988565488 endingPage "188" @default.
- W1988565488 startingPage "175" @default.
- W1988565488 abstract "Plasma high density lipoprotein cholesterol (HDL) comprises a heterogeneous family of lipoprotein species, differing in surface charge, size and lipid and protein compositions. While HDL cholesterol (C) mass is a strong, graded and coherent biomarker of cardiovascular risk, genetic and clinical trial data suggest that the simple measurement of HDL-C may not be causal in preventing atherosclerosis nor reflect HDL functionality. Indeed, the measurement of HDL-C may be a biomarker of cardiovascular health. To assess the issue of HDL function as a potential therapeutic target, robust and simple analytical methods are required. The complex pleiotropic effects of HDL make the development of a single measurement challenging. Development of laboratory assays that accurately HDL function must be developed validated and brought to high-throughput for clinical purposes. This review discusses the limitations of current laboratory technologies for methods that separate and quantify HDL and potential application to predict CVD, with an emphasis on emergent approaches as potential biomarkers in clinical practice." @default.
- W1988565488 created "2016-06-24" @default.
- W1988565488 creator A5022102417 @default.
- W1988565488 creator A5049902805 @default.
- W1988565488 date "2015-06-01" @default.
- W1988565488 modified "2023-10-16" @default.
- W1988565488 title "High density lipoproteins: Measurement techniques and potential biomarkers of cardiovascular risk" @default.
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