FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988591758> ?p ?o ?g. }

• W1988591758 endingPage "272" @default.
• W1988591758 startingPage "265" @default.
• W1988591758 abstract "The development of the hamster visual system is accompanied by striking changes in the pattern of proteins that are synthesized in retinal ganglion cells and rapidly transported to their nerve terminals. To determine whether any of these protein changes are regulated by interactions between the developing nerve endings and the cells with which they form synapses, we induced retinofugal axons to form abnormal projections in the lateral posterior (LP) nucleus of the thalamus and dense patches of hyperinnervation in the lateral geniculate nucleus (LGN) by removing their principal target, the superior colliculus (SC), the day after birth. Under these experimental conditions, two rapidly transported proteins, including the neural cell adhesion molecule, NCAM, showed significant changes in their time course of expression. NCAM, identified here using a monospecific antibody, is normally synthesized and transported at high levels at early stages of development and then declines during the second and third postnatal weeks. However, this decline was delayed when optic fibers were re-routed. A second rapidly transported protein, M(r) = 67 kDa, pI = 4.7, normally shows a rise in its synthesis and transport during terminal arbor formation and a subsequent decline, but it also remained elevated for a prolonged period when the SC was absent. These findings cannot be accounted for by a simple delay in the retinal ganglion cells' program of axonal growth, since other rapidly transported proteins, including the growth-associated protein GAP-43, showed a normal developmental time-course when the SC was removed. Target interactions therefore appear to influence the retinal ganglion cells' expression of different proteins in a specific fashion." @default.
• W1988591758 created "2016-06-24" @default.
• W1988591758 creator A5013945113 @default.
• W1988591758 creator A5018098888 @default.
• W1988591758 creator A5062792567 @default.
• W1988591758 creator A5091495583 @default.
• W1988591758 date "1992-07-01" @default.
• W1988591758 modified "2023-10-14" @default.
• W1988591758 title "Changes in rapidly transported proteins associated with development of abnormal projections in the diencephalon" @default.
• W1988591758 cites W1484410831 @default.
• W1988591758 cites W1484816752 @default.
• W1988591758 cites W1487230561 @default.
• W1988591758 cites W1516340190 @default.
• W1988591758 cites W1593217211 @default.
• W1988591758 cites W1606423922 @default.
• W1988591758 cites W1646353701 @default.
• W1988591758 cites W1762897903 @default.
• W1988591758 cites W1898295630 @default.
• W1988591758 cites W1937056995 @default.
• W1988591758 cites W1966801871 @default.
• W1988591758 cites W1967624605 @default.
• W1988591758 cites W1970259762 @default.
• W1988591758 cites W1979193543 @default.
• W1988591758 cites W1980140013 @default.
• W1988591758 cites W1982362264 @default.
• W1988591758 cites W1984398513 @default.
• W1988591758 cites W1986564479 @default.
• W1988591758 cites W1993196714 @default.
• W1988591758 cites W2004345215 @default.
• W1988591758 cites W2009475761 @default.
• W1988591758 cites W2010620346 @default.
• W1988591758 cites W2013727967 @default.
• W1988591758 cites W2013970232 @default.
• W1988591758 cites W2015414605 @default.
• W1988591758 cites W2018540696 @default.
• W1988591758 cites W2033844723 @default.
• W1988591758 cites W2037230002 @default.
• W1988591758 cites W2039638079 @default.
• W1988591758 cites W2040217534 @default.
• W1988591758 cites W2048269912 @default.
• W1988591758 cites W2050772280 @default.
• W1988591758 cites W2063800444 @default.
• W1988591758 cites W2067242056 @default.
• W1988591758 cites W2069331174 @default.
• W1988591758 cites W2077906208 @default.
• W1988591758 cites W2082106963 @default.
• W1988591758 cites W2085247156 @default.
• W1988591758 cites W2086126673 @default.
• W1988591758 cites W2099153019 @default.
• W1988591758 cites W2103920508 @default.
• W1988591758 cites W2131331811 @default.
• W1988591758 cites W2139663093 @default.
• W1988591758 cites W2478629109 @default.
• W1988591758 cites W89988927 @default.
• W1988591758 cites W2013698386 @default.
• W1988591758 doi "https://doi.org/10.1016/0006-8993(92)91635-r" @default.
• W1988591758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1381651" @default.
• W1988591758 hasPublicationYear "1992" @default.
• W1988591758 type Work @default.
• W1988591758 sameAs 1988591758 @default.
• W1988591758 citedByCount "9" @default.
• W1988591758 crossrefType "journal-article" @default.
• W1988591758 hasAuthorship W1988591758A5013945113 @default.
• W1988591758 hasAuthorship W1988591758A5018098888 @default.
• W1988591758 hasAuthorship W1988591758A5062792567 @default.
• W1988591758 hasAuthorship W1988591758A5091495583 @default.
• W1988591758 hasConcept C169760540 @default.
• W1988591758 hasConcept C2775969318 @default.
• W1988591758 hasConcept C2776362945 @default.
• W1988591758 hasConcept C2777093970 @default.
• W1988591758 hasConcept C2777624874 @default.
• W1988591758 hasConcept C2779246727 @default.
• W1988591758 hasConcept C2780723820 @default.
• W1988591758 hasConcept C2780827179 @default.
• W1988591758 hasConcept C2780837183 @default.
• W1988591758 hasConcept C2781334511 @default.
• W1988591758 hasConcept C2781416072 @default.
• W1988591758 hasConcept C529278444 @default.
• W1988591758 hasConcept C55493867 @default.
• W1988591758 hasConcept C70192387 @default.
• W1988591758 hasConcept C86803240 @default.
• W1988591758 hasConcept C95444343 @default.
• W1988591758 hasConceptScore W1988591758C169760540 @default.
• W1988591758 hasConceptScore W1988591758C2775969318 @default.
• W1988591758 hasConceptScore W1988591758C2776362945 @default.
• W1988591758 hasConceptScore W1988591758C2777093970 @default.
• W1988591758 hasConceptScore W1988591758C2777624874 @default.
• W1988591758 hasConceptScore W1988591758C2779246727 @default.
• W1988591758 hasConceptScore W1988591758C2780723820 @default.
• W1988591758 hasConceptScore W1988591758C2780827179 @default.
• W1988591758 hasConceptScore W1988591758C2780837183 @default.
• W1988591758 hasConceptScore W1988591758C2781334511 @default.
• W1988591758 hasConceptScore W1988591758C2781416072 @default.
• W1988591758 hasConceptScore W1988591758C529278444 @default.
• W1988591758 hasConceptScore W1988591758C55493867 @default.
• W1988591758 hasConceptScore W1988591758C70192387 @default.
• W1988591758 hasConceptScore W1988591758C86803240 @default.
• W1988591758 hasConceptScore W1988591758C95444343 @default.

• next