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- W1988598520 abstract "Abstract: Agranulocytosis developed in a 63-year-old patient with myelodysplasia 6 weeks after commencing treatment with the oral iron chelator deferiprone (L1, 1,2-dimethyl-3-hydroxypyrid-4-one, CP20) at a daily dose of 79 mg/kg. This was the 3rd case of agranulocytosis (neutrophils 0 times 109/***1) in clinical trials of L1 at the Royal Free Hospital. The neutrophil count recovered 7 days after stopping and commencing G-CSF at a dose of 300 μg daily. Three other patients with milder degrees of neutropenia (neutrophils <1.5 times 109/1) have also been observed in our trials. The case histories of these 4 patients are described here; other reported cases of neutropenia or agranulocytosis are reviewed. Based on worldwide long-term clinical trials the incidence of agranulocytosis is about 1.6% and of neutropenia 2%." @default.
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- W1988598520 date "2009-04-24" @default.
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- W1988598520 title "Deferiprone-associated myelotoxicity" @default.
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- W1988598520 doi "https://doi.org/10.1111/j.1600-0609.1994.tb01323.x" @default.
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