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• W1988601069 abstract "Permeability coefficients for 114 compounds across excised human skin in vitro were taken from Kirchner et al. Forty-seven descriptors were calculated encompassing the relevant physicochemical parameters of the compounds. Quantitative structure-permeability relationships (QSPRs) were developed using least-squares regression analysis. A two-parameter QSPR, describing the permeability coefficients (Kp) across excised skin, was obtained: log Kp=0.772 log P -0.0103 Mr - 2.33 where log P is the logarithm of the octanol-water partition coefficient and Mr is molecular mass. This equation indicates that percutaneous absorption is mediated by the hydrophobicity and the molecular size of the penetrant. Comparison with a QSPR based on penetration across a synthetic (polydimethylsiloxane) membrane suggests that the mechanisms of drug flux across polydimethylsiloxane membranes and excised human skin are significantly different." @default.
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• W1988601069 date "1999-03-01" @default.
• W1988601069 modified "2023-10-18" @default.
• W1988601069 title "Investigation of the mechanism of flux across human skin in vitro by quantitative structure–permeability relationships" @default.
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• W1988601069 doi "https://doi.org/10.1016/s0928-0987(98)00041-4" @default.
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