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- W1988602004 abstract "Episodic fluctuations of FSH, LH, prolactin (PRL) and testosterone (T) were determined in male and female lambs from birth to 2 months of age. Plasma LH and FSH peaks were observed from the first week of life but plasma LH was not consistently followed by an increase in T at 8 weeks. Although plasma FSH and PRL fluctuated with no specific trend observable, plasma FSH was higher in female than in male lambs. During a 6 h observation period, fewer spontaneous peaks of LH or T were observed at 4 weeks than at 2 or 8 weeks of age. A significant in vivo T response to hCG administration at 2, 4 and 8 weeks was observed but the mean T area was greater at 8 weeks. These studies indicate an active hypothalamic-pituitary axis in the newborn lamb of both sexes and early testicular activity. However, the steroidogenic testicular responsiveness to endogenous LH appears to be lower at 8 than at 2 weeks of life. The existence of an early activation of the pituitary gonadal axis in the immature male lamb would suggest its usefulness as an experimental model for the study of early postnatal gonadal activity in man." @default.
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- W1988602004 date "1979-12-01" @default.
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- W1988602004 title "Perinatal Activity of the Hypothalamic-Pituitary-Gonadal Axis in the Lamb. I. Circulating Levels of LH, FSH, Prolactin and Testosterone and in vivo Response to hCG in the First Two Months of Life" @default.
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- W1988602004 doi "https://doi.org/10.1095/biolreprod21.5.1051" @default.
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