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• W1988645118 abstract "The cytochrome caa3 complex from Bacillus subtilis is a member of the cytochrome oxidase superfamily of respiratory enzyme complexes. The key difference in the cytochrome caa3 complex lies in the addition of a domain, homologous with mitochondrial cytochrome c, that is fused to the C-terminal end of its subunit II. Measurements of steady-state and transient reduction kinetics have been carried out on the cytochrome caa3 complex. Reduction of the cyanide-bound enzyme with ascorbate and N,N,N‘,N‘-tetramethyl-p-phenylenediamine (TMPD) supports a sequence of electron transfer in which cytochrome c is reduced initially, and this is followed by rapid internal electron transfer from cytochrome c to CuA and from CuA to cytochrome a. Steady-state kinetics with exogenous cytochrome c as the substrate demonstrates the capability of the cytochrome caa3 complex to act as a cytochrome c oxidase. The cytochrome c from B. subtilis is the most efficient cytochrome c of those tested. Steady-state kinetics with ascorbate−TMPD as the reductant, in the absence of exogenous cytochrome c, reveals a biphasic pattern even though only a single, covalent cytochrome c interaction site is present. The two-phase kinetics are characterized by a low activity phase associated with a high apparent affinity for TMPD and a high activity phase with a low affinity for TMPD. This pattern is observed over a wide range of ionic strengths and enzyme concentrations, and with both purified and membrane extract forms of cytochrome caa3. It is proposed that the biphasic steady-state kinetics of this oxidase, and other members of the cytochrome oxidase superfamily, do not result directly from different interactions with cytochrome c but are due to a change in the redox kinetics within the centers of the conventional oxidase unit itself. Our results will be related to models that account for the biphasic steady-state kinetics exhibited by cytochrome oxidase." @default.
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• W1988645118 date "1998-06-19" @default.
• W1988645118 modified "2023-09-26" @default.
• W1988645118 title "Electron Transfer Kinetics during the Reduction and Turnover of the Cytochrome <i>caa</i>₃ Complex from <i>Bacillus subtilis</i>" @default.
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• W1988645118 doi "https://doi.org/10.1021/bi980331c" @default.
• W1988645118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9665704" @default.
• W1988645118 hasPublicationYear "1998" @default.
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