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- W1988653485 abstract "Sir, Topical photodynamic therapy (PDT) with δ‐5‐aminolaevulinic acid (5‐ALA) is increasingly used in precancerous skin lesions (actinic keratoses) and nonmelanoma skin cancer [superficial basal cell carcinoma (BCC); Bowen's disease].1 The mechanism of PDT depends on the activation of a photosensitizing compound by visible light of an appropriate wavelength that correlates with the absorption spectrum of the photosensitizing compound in the presence of molecular oxygen. The exogenous prodrug 5‐ALA is converted intracellularly to the endogenous photosensitizer protoporphyrin IX, with preferential accumulation in neoplastic/dysplastic tissue and consequent absorption of photons.2 This latter results in a cascade of events, in which apoptosis has been suggested to play an important role.3 In the present study, we have investigated the possible role of apoptosis by the sequential analysis of lesional skin after 5‐ALA‐PDT (5‐ALA in a 20% oil‐in‐water emulsion under occlusion, and visible light by the lamp Fotoec 3 H250, Loto, Florence, Italy: wavelength within the 630‐nm range) in eight patients with superficial BCC after informed consent. The neoplastic skin samples were collected 15 min and 4, 24, 48 and 72 h after the irradiation in order to investigate the possible modifications at the cellular and subcellular level (by electron microscopy), the expression of apoptotic markers [alkaline phosphatase–antialkaline phosphatase (APAAP) and terminal deoxynucleotidyl transferase‐mediated deoxyuridine triphosphate nick end labelling (TUNEL) methods], and the immunophenotypic profile of the inflammatory cell infiltrate (APAAP)." @default.
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- W1988653485 date "2003-07-01" @default.
- W1988653485 modified "2023-09-27" @default.
- W1988653485 title "Early apoptosis plays an important role in the healing mechanism of cutaneous basal cell carcinomas after photodynamic therapy" @default.
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- W1988653485 doi "https://doi.org/10.1046/j.1365-2133.2003.05396.x" @default.
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