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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988656670> ?p ?o ?g. }

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• W1988656670 abstract "Tuberculosis (TB) is an important disease that causes thousands of deaths around the world. Resistance against antitubercular available drugs has been reported; so, research on new effective antimycobacterial molecules is needed. Antimycobacterial activity of three lignans and two synthetic hydrazones was assessed against Mycobacterium tuberculosis H37Rv by antimycobacterial microdilution assay (TEMA). An oxadiazoline (AC451) and a lignan (ethoxycubebin) were the most active compounds (MIC 6.09 and 62.4 μM, resp.). Several changes in mycolic acid profile of treated bacteria were detected with both compounds by mass spectrometry analysis. Additionally, the level of reduction of mycolic acids in ethoxycubebin treatment was correlated to disruption in bacterial morphology." @default.
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• W1988656670 date "2011-01-01" @default.
• W1988656670 modified "2023-10-18" @default.
• W1988656670 title "Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes ofMycobacterium tuberculosis" @default.
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• W1988656670 doi "https://doi.org/10.1155/2011/986409" @default.
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