FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988656902> ?p ?o ?g. }

• W1988656902 endingPage "687" @default.
• W1988656902 startingPage "681" @default.
• W1988656902 abstract "Rats were implanted with chronically indwelling gastric and intracerebral cannulae for the analysis of the hypothalamic sites and mechanisms of action of the dopamine agonist, 2-di-n-propylamino-5,6-dihydroxytetralin, to reduce the volume of gastric secretion and concentration of acid. The hypothalamic areas most sensitive to the actions of the tetralin compound to modify gastric secretion were the ventromedial and dorsomedial nuclei. Movement of the injection site 0.5 or 1.0 mm away from the ventromedial and dorsomedial nuclei in the anterior, posterior or lateral direction led to reduced effectiveness, or loss of action. In a study restricted to the ventromedial nucleus of the hypothalamus, the tetralin compound (0.1-5 micrograms) was shown to cause dose-dependent changes in gastric secretion, the reduction in concentration of acid being antagonised by the neuroleptic agents, sulpiride, metoclopramide, cis-flupenthixol and haloperidol, and by the alpha 2-adrenoceptor antagonist, yohimbine injected at the same site. The reduction in secretory volume was antagonised by propranolol. Thus, a locus specificity was shown for the action of the tetralin compound in the dorsomedial and ventromedial hypothalamic nuclei of the rat, to reduce the volume of gastric secretion and concentration of acid. Such actions, as assessed in the ventromedial nucleus, are initiated via neuroleptic-sensitive, dopamine receptor mechanisms with additional involvement of alpha 2-adrenoceptors in the control of change in concentration of acid, and beta-adrenoceptors in the change in volume of secretion." @default.
• W1988656902 created "2016-06-24" @default.
• W1988656902 creator A5036115757 @default.
• W1988656902 creator A5060211915 @default.
• W1988656902 creator A5064381958 @default.
• W1988656902 date "1986-07-01" @default.
• W1988656902 modified "2023-09-27" @default.
• W1988656902 title "The sites and mechanisms of action of 2-DI-n-propylamino-5,6-dihydroxytetralin in the hypothalamus of the rat to modify gastric secretion" @default.
• W1988656902 cites W1931482045 @default.
• W1988656902 cites W1966897527 @default.
• W1988656902 cites W1975709498 @default.
• W1988656902 cites W1988154987 @default.
• W1988656902 cites W1993425740 @default.
• W1988656902 cites W1996172297 @default.
• W1988656902 cites W2002674925 @default.
• W1988656902 cites W2006052527 @default.
• W1988656902 cites W2017322614 @default.
• W1988656902 cites W2044113321 @default.
• W1988656902 cites W2078124639 @default.
• W1988656902 cites W2149454872 @default.
• W1988656902 cites W2300832093 @default.
• W1988656902 cites W2305352979 @default.
• W1988656902 cites W2431316979 @default.
• W1988656902 cites W2501241271 @default.
• W1988656902 cites W275872826 @default.
• W1988656902 doi "https://doi.org/10.1016/0028-3908(86)90082-1" @default.
• W1988656902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2875416" @default.
• W1988656902 hasPublicationYear "1986" @default.
• W1988656902 type Work @default.
• W1988656902 sameAs 1988656902 @default.
• W1988656902 citedByCount "2" @default.
• W1988656902 crossrefType "journal-article" @default.
• W1988656902 hasAuthorship W1988656902A5036115757 @default.
• W1988656902 hasAuthorship W1988656902A5060211915 @default.
• W1988656902 hasAuthorship W1988656902A5064381958 @default.
• W1988656902 hasConcept C126322002 @default.
• W1988656902 hasConcept C134018914 @default.
• W1988656902 hasConcept C137183658 @default.
• W1988656902 hasConcept C170493617 @default.
• W1988656902 hasConcept C185592680 @default.
• W1988656902 hasConcept C202751555 @default.
• W1988656902 hasConcept C2776046087 @default.
• W1988656902 hasConcept C2776120743 @default.
• W1988656902 hasConcept C2776885963 @default.
• W1988656902 hasConcept C2777003273 @default.
• W1988656902 hasConcept C2777504413 @default.
• W1988656902 hasConcept C2777676773 @default.
• W1988656902 hasConcept C2778479196 @default.
• W1988656902 hasConcept C2778938600 @default.
• W1988656902 hasConcept C2780806966 @default.
• W1988656902 hasConcept C2780852908 @default.
• W1988656902 hasConcept C2780948584 @default.
• W1988656902 hasConcept C49039625 @default.
• W1988656902 hasConcept C513476851 @default.
• W1988656902 hasConcept C55493867 @default.
• W1988656902 hasConcept C71924100 @default.
• W1988656902 hasConcept C86803240 @default.
• W1988656902 hasConcept C98274493 @default.
• W1988656902 hasConceptScore W1988656902C126322002 @default.
• W1988656902 hasConceptScore W1988656902C134018914 @default.
• W1988656902 hasConceptScore W1988656902C137183658 @default.
• W1988656902 hasConceptScore W1988656902C170493617 @default.
• W1988656902 hasConceptScore W1988656902C185592680 @default.
• W1988656902 hasConceptScore W1988656902C202751555 @default.
• W1988656902 hasConceptScore W1988656902C2776046087 @default.
• W1988656902 hasConceptScore W1988656902C2776120743 @default.
• W1988656902 hasConceptScore W1988656902C2776885963 @default.
• W1988656902 hasConceptScore W1988656902C2777003273 @default.
• W1988656902 hasConceptScore W1988656902C2777504413 @default.
• W1988656902 hasConceptScore W1988656902C2777676773 @default.
• W1988656902 hasConceptScore W1988656902C2778479196 @default.
• W1988656902 hasConceptScore W1988656902C2778938600 @default.
• W1988656902 hasConceptScore W1988656902C2780806966 @default.
• W1988656902 hasConceptScore W1988656902C2780852908 @default.
• W1988656902 hasConceptScore W1988656902C2780948584 @default.
• W1988656902 hasConceptScore W1988656902C49039625 @default.
• W1988656902 hasConceptScore W1988656902C513476851 @default.
• W1988656902 hasConceptScore W1988656902C55493867 @default.
• W1988656902 hasConceptScore W1988656902C71924100 @default.
• W1988656902 hasConceptScore W1988656902C86803240 @default.
• W1988656902 hasConceptScore W1988656902C98274493 @default.
• W1988656902 hasIssue "7" @default.
• W1988656902 hasLocation W19886569021 @default.
• W1988656902 hasLocation W19886569022 @default.
• W1988656902 hasOpenAccess W1988656902 @default.
• W1988656902 hasPrimaryLocation W19886569021 @default.
• W1988656902 hasRelatedWork W1988656902 @default.
• W1988656902 hasRelatedWork W1994492867 @default.
• W1988656902 hasRelatedWork W2007920416 @default.
• W1988656902 hasRelatedWork W2058173101 @default.
• W1988656902 hasRelatedWork W2062579683 @default.
• W1988656902 hasRelatedWork W2099105653 @default.
• W1988656902 hasRelatedWork W2271274515 @default.
• W1988656902 hasRelatedWork W2315166476 @default.
• W1988656902 hasRelatedWork W330934547 @default.
• W1988656902 hasRelatedWork W2413510397 @default.
• W1988656902 hasVolume "25" @default.
• W1988656902 isParatext "false" @default.

• next