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- W1988657646 abstract "The effects of recombinant human interferon-alpha (IFN-alpha) and naloxone (NLX) were studied on the single neuron activities of the preoptic and anterior hypothalamus (PO/AH) and the ventromedial hypothalamus (VMH) in tissue slices. Perfusion of IFN-alpha in physiological doses (10-5000 units/ml) decreased and increased the firing rate of the majority of PO/AH and VMH neurons respectively. The IFN-alpha-induced changes in firing rate of PO/AH and VMH neurons were reversibly blocked or attenuated by simultaneous application of NLX. The results suggest that IFN-alpha may exert its action through opiate receptors in the hypothalamus." @default.
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- W1988657646 date "1987-12-01" @default.
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- W1988657646 title "Naloxone blocks the interferon-α induced changes in hypothalamic neuronal activity" @default.
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- W1988657646 doi "https://doi.org/10.1016/0304-3940(87)90278-3" @default.
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