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• W1988668049 abstract "Polyunsaturated fatty acids influence the aetiology of prostate cancer. Their effects on cellular mechanisms regulating prostate tumorigenesis are unclear. Using prostate cancer cells (LNCaP), we determined effects of n-9-OA, n-6-LA, and n-3-EPA on total PKC and its isoforms in relation to cell proliferation and PSA production. PKC-α, δ, γ, ι, μ, and ζ were present in LNCaP cells; PKC-β, ϵ, η, and θ isoforms were not. PKC-α was detected only in cytosol; PKC-δ, ι, γ, and μ were present in cytosol and in membranes. Fatty acids increased cell proliferation, total PKC activity and elicited pro-proliferative effects on specific PKC isoforms (PKC-δ and -ι). EPA and LA increased total PKC activity and reduced membrane-abundance of PKC-δ. OA reduced cytosolic and membrane PKC-δ. Only EPA reduced PKC-γ membrane abundance. Fatty acids enhanced cytosolic PKC-ι abundance but only EPA and to a lesser extent LA increased its membrane content. Changes in PKC-δ, -ι, and -γ did not affect PSA production." @default.
• W1988668049 created "2016-06-24" @default.
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• W1988668049 date "2001-05-01" @default.
• W1988668049 modified "2023-09-27" @default.
• W1988668049 title "Fatty Acid Regulation of Protein Kinase C Isoforms in Prostate Cancer Cells" @default.
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• W1988668049 doi "https://doi.org/10.1006/bbrc.2001.4873" @default.
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