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- W1988693228 abstract "Abstract Since cyclocytidine primarily inhibits the incorporation ofthymidine into DNA of cultured cells, the inhibition of DNA polymerase by some cyclocytidine derivatives was examined. Cyclocytidine 5'-monophosphate (cycloCMP) and aracytidine 5'-monophosphate (araCMP) markedly inhibited DNA polymerase, whereas cyclocytidine and aracytidine did not inhibit the enzyme in cell-free systems. Inhibitory potency of cyclo-CMP was about 1/15th that of araCMP. The possibility of phosphorylation of cyclo-cytidine to cyclo CMP was also examined, and it was revealed that cyclocytidine was phosphorylated at a rate 1/7th that of aracytidine or 1/10th that of deoxycytidine." @default.
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- W1988693228 date "1973-11-01" @default.
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- W1988693228 title "Effect of phosphorylated cyclocytidine on deoxyribonucleic acid polymerase" @default.
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- W1988693228 doi "https://doi.org/10.1016/0006-2952(73)90149-4" @default.
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