FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988697665> ?p ?o ?g. }

• W1988697665 endingPage "446" @default.
• W1988697665 startingPage "442" @default.
• W1988697665 abstract "ABSTRACT: Membrane properties associated with chemoattractant-mediated cellular responsiveness of neonatal polymorphonuclear leukocytes (PMN) were analyzed using n-formylmethionyl-leucyl-phenylalanine. Inasmuch as aliphatic alcohols as a membrane fluidizer can enhance the chemoattractant binding and affect subsequent cellular responsiveness in adult PMN, neonatal PMN were studied for such properties by their treatment with iso-propyl alcohol, an aliphatic alcohol. The alcohol (<2.5%) treatment enhanced the N-formylmethionyl-leucyl-phenylalanine binding to adult PMN, but there were no changes in the N-formylmethionyl-leucyl-phenylalanine binding to neonatal PMN. Although the N-formylmethionyl-leucyl-phenylalanine-induced subsequent responsiveness including migration, lysosomal enzyme release and superoxide anion production were modulated by the alcohol treatment in adult PMN, there was no such modulation in neonatal PMN. Because membrane fluidity is largely involved in the regulation of the receptor functions, the membrane fluidity of neonatal PMN was next measured by an excimer-forming lipid technique in flow cytometry. The membrane fluidity value (0.45 ± 0.037) of neonatal PMN was lower than that (0.74 ± 0.072) of adult PMN (p < 0.01). Although the aliphatic alcohol enhanced the membrane fluidity of adult PMN, it did not affect the membrane fluidity of neonatal PMN. We conclude that there is abnormal membrane fluidity as a cause of impaired functional dynamics of the chemoattractant receptors, which appears to underlie the defective modulation of cell functions by the membrane fluidizer in neonatal PMN." @default.
• W1988697665 created "2016-06-24" @default.
• W1988697665 creator A5019604224 @default.
• W1988697665 creator A5030576470 @default.
• W1988697665 creator A5032856968 @default.
• W1988697665 creator A5043986012 @default.
• W1988697665 creator A5061148658 @default.
• W1988697665 creator A5068749883 @default.
• W1988697665 creator A5069874728 @default.
• W1988697665 creator A5077406348 @default.
• W1988697665 creator A5082526106 @default.
• W1988697665 date "1988-10-01" @default.
• W1988697665 modified "2023-10-18" @default.
• W1988697665 title "Abnormal Membrane Fluidity as a Cause of Impaired Functional Dynamics of Chemoattractant Receptors on Neonatal Polymorphonuclear Leukocytes: Lack of Modulation of the Receptors by a Membrane Fluidizer" @default.
• W1988697665 cites W1028050129 @default.
• W1988697665 cites W1508769591 @default.
• W1988697665 cites W1517499104 @default.
• W1988697665 cites W1582257691 @default.
• W1988697665 cites W1677371761 @default.
• W1988697665 cites W1819732475 @default.
• W1988697665 cites W1965793738 @default.
• W1988697665 cites W1968762921 @default.
• W1988697665 cites W1976041987 @default.
• W1988697665 cites W1984989435 @default.
• W1988697665 cites W2000390354 @default.
• W1988697665 cites W2004999070 @default.
• W1988697665 cites W2012982812 @default.
• W1988697665 cites W2013055993 @default.
• W1988697665 cites W2016765240 @default.
• W1988697665 cites W2037157726 @default.
• W1988697665 cites W2039348809 @default.
• W1988697665 cites W2070556051 @default.
• W1988697665 cites W2072743252 @default.
• W1988697665 cites W2080662368 @default.
• W1988697665 cites W2087773962 @default.
• W1988697665 cites W2088315418 @default.
• W1988697665 cites W2091934678 @default.
• W1988697665 cites W2119097766 @default.
• W1988697665 cites W2136789358 @default.
• W1988697665 cites W2209591732 @default.
• W1988697665 cites W2282755628 @default.
• W1988697665 cites W2411083179 @default.
• W1988697665 cites W2412223002 @default.
• W1988697665 cites W2434882626 @default.
• W1988697665 doi "https://doi.org/10.1203/00006450-198810000-00005" @default.
• W1988697665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2845343" @default.
• W1988697665 hasPublicationYear "1988" @default.
• W1988697665 type Work @default.
• W1988697665 sameAs 1988697665 @default.
• W1988697665 citedByCount "30" @default.
• W1988697665 countsByYear W19886976652013 @default.
• W1988697665 countsByYear W19886976652023 @default.
• W1988697665 crossrefType "journal-article" @default.
• W1988697665 hasAuthorship W1988697665A5019604224 @default.
• W1988697665 hasAuthorship W1988697665A5030576470 @default.
• W1988697665 hasAuthorship W1988697665A5032856968 @default.
• W1988697665 hasAuthorship W1988697665A5043986012 @default.
• W1988697665 hasAuthorship W1988697665A5061148658 @default.
• W1988697665 hasAuthorship W1988697665A5068749883 @default.
• W1988697665 hasAuthorship W1988697665A5069874728 @default.
• W1988697665 hasAuthorship W1988697665A5077406348 @default.
• W1988697665 hasAuthorship W1988697665A5082526106 @default.
• W1988697665 hasBestOaLocation W19886976651 @default.
• W1988697665 hasConcept C122398194 @default.
• W1988697665 hasConcept C12554922 @default.
• W1988697665 hasConcept C126322002 @default.
• W1988697665 hasConcept C134018914 @default.
• W1988697665 hasConcept C170493617 @default.
• W1988697665 hasConcept C181199279 @default.
• W1988697665 hasConcept C185592680 @default.
• W1988697665 hasConcept C197462201 @default.
• W1988697665 hasConcept C2780795997 @default.
• W1988697665 hasConcept C41625074 @default.
• W1988697665 hasConcept C54166955 @default.
• W1988697665 hasConcept C55493867 @default.
• W1988697665 hasConcept C71924100 @default.
• W1988697665 hasConcept C86803240 @default.
• W1988697665 hasConceptScore W1988697665C122398194 @default.
• W1988697665 hasConceptScore W1988697665C12554922 @default.
• W1988697665 hasConceptScore W1988697665C126322002 @default.
• W1988697665 hasConceptScore W1988697665C134018914 @default.
• W1988697665 hasConceptScore W1988697665C170493617 @default.
• W1988697665 hasConceptScore W1988697665C181199279 @default.
• W1988697665 hasConceptScore W1988697665C185592680 @default.
• W1988697665 hasConceptScore W1988697665C197462201 @default.
• W1988697665 hasConceptScore W1988697665C2780795997 @default.
• W1988697665 hasConceptScore W1988697665C41625074 @default.
• W1988697665 hasConceptScore W1988697665C54166955 @default.
• W1988697665 hasConceptScore W1988697665C55493867 @default.
• W1988697665 hasConceptScore W1988697665C71924100 @default.
• W1988697665 hasConceptScore W1988697665C86803240 @default.
• W1988697665 hasIssue "4" @default.
• W1988697665 hasLocation W19886976651 @default.
• W1988697665 hasLocation W19886976652 @default.
• W1988697665 hasOpenAccess W1988697665 @default.
• W1988697665 hasPrimaryLocation W19886976651 @default.
• W1988697665 hasRelatedWork W1996846474 @default.
• W1988697665 hasRelatedWork W2018368842 @default.

• next