Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988698678> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1988698678 endingPage "7198" @default.
- W1988698678 startingPage "7190" @default.
- W1988698678 abstract "Novel nitrogenous diterpenoids, spongolactams A-C (1-3), were isolated as trace components of an Okinawan marine sponge, Spongia sp., by an LC/MS-guided assay for farnesyl transferase (FTase) inhibitors. Their structures were elucidated by spectroscopic analyses. To evaluate their structures and biological activity, the metabolites were semisynthesized from the known furanoditerpene 5, obtained from the same sponge. Three related compounds 4, 13, and 16 were also semisynthesized. The IC50 values against FTase for 1-3 were 23, 130, and >260 microM, respectively, while the IC50 values against a human tumor cell line were 2.0, 3.5, and 20 microM, respectively. The structure-activity relationships within the six compounds suggest some positive correlation between FTase inhibitory and cytotoxic activities." @default.
- W1988698678 created "2016-06-24" @default.
- W1988698678 creator A5002252113 @default.
- W1988698678 creator A5021763788 @default.
- W1988698678 creator A5037351086 @default.
- W1988698678 creator A5044663343 @default.
- W1988698678 creator A5046771313 @default.
- W1988698678 creator A5051302622 @default.
- W1988698678 creator A5077489438 @default.
- W1988698678 creator A5086372970 @default.
- W1988698678 date "2007-08-22" @default.
- W1988698678 modified "2023-10-18" @default.
- W1988698678 title "Spongolactams, Farnesyl Transferase Inhibitors from a Marine Sponge: Isolation through an LC/MS-Guided Assay, Structures, and Semisyntheses" @default.
- W1988698678 cites W119730758 @default.
- W1988698678 cites W1483337170 @default.
- W1988698678 cites W1538564037 @default.
- W1988698678 cites W1544277307 @default.
- W1988698678 cites W1972240604 @default.
- W1988698678 cites W1982917261 @default.
- W1988698678 cites W2011301807 @default.
- W1988698678 cites W2012100308 @default.
- W1988698678 cites W2017407373 @default.
- W1988698678 cites W2037111917 @default.
- W1988698678 cites W2045416407 @default.
- W1988698678 cites W2074741811 @default.
- W1988698678 cites W2079517986 @default.
- W1988698678 cites W2088704260 @default.
- W1988698678 cites W2160553642 @default.
- W1988698678 cites W2178557511 @default.
- W1988698678 cites W2218331703 @default.
- W1988698678 cites W2951933011 @default.
- W1988698678 doi "https://doi.org/10.1021/jo071003y" @default.
- W1988698678 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17713950" @default.
- W1988698678 hasPublicationYear "2007" @default.
- W1988698678 type Work @default.
- W1988698678 sameAs 1988698678 @default.
- W1988698678 citedByCount "36" @default.
- W1988698678 countsByYear W19886986782012 @default.
- W1988698678 countsByYear W19886986782013 @default.
- W1988698678 countsByYear W19886986782014 @default.
- W1988698678 countsByYear W19886986782015 @default.
- W1988698678 countsByYear W19886986782016 @default.
- W1988698678 countsByYear W19886986782017 @default.
- W1988698678 countsByYear W19886986782018 @default.
- W1988698678 countsByYear W19886986782019 @default.
- W1988698678 countsByYear W19886986782020 @default.
- W1988698678 countsByYear W19886986782023 @default.
- W1988698678 crossrefType "journal-article" @default.
- W1988698678 hasAuthorship W1988698678A5002252113 @default.
- W1988698678 hasAuthorship W1988698678A5021763788 @default.
- W1988698678 hasAuthorship W1988698678A5037351086 @default.
- W1988698678 hasAuthorship W1988698678A5044663343 @default.
- W1988698678 hasAuthorship W1988698678A5046771313 @default.
- W1988698678 hasAuthorship W1988698678A5051302622 @default.
- W1988698678 hasAuthorship W1988698678A5077489438 @default.
- W1988698678 hasAuthorship W1988698678A5086372970 @default.
- W1988698678 hasConcept C185592680 @default.
- W1988698678 hasConcept C202751555 @default.
- W1988698678 hasConcept C2777752497 @default.
- W1988698678 hasConcept C2778849931 @default.
- W1988698678 hasConcept C55493867 @default.
- W1988698678 hasConcept C59822182 @default.
- W1988698678 hasConcept C71240020 @default.
- W1988698678 hasConcept C86803240 @default.
- W1988698678 hasConceptScore W1988698678C185592680 @default.
- W1988698678 hasConceptScore W1988698678C202751555 @default.
- W1988698678 hasConceptScore W1988698678C2777752497 @default.
- W1988698678 hasConceptScore W1988698678C2778849931 @default.
- W1988698678 hasConceptScore W1988698678C55493867 @default.
- W1988698678 hasConceptScore W1988698678C59822182 @default.
- W1988698678 hasConceptScore W1988698678C71240020 @default.
- W1988698678 hasConceptScore W1988698678C86803240 @default.
- W1988698678 hasIssue "19" @default.
- W1988698678 hasLocation W19886986781 @default.
- W1988698678 hasLocation W19886986782 @default.
- W1988698678 hasOpenAccess W1988698678 @default.
- W1988698678 hasPrimaryLocation W19886986781 @default.
- W1988698678 hasRelatedWork W2008060982 @default.
- W1988698678 hasRelatedWork W2088180967 @default.
- W1988698678 hasRelatedWork W2095130203 @default.
- W1988698678 hasRelatedWork W2469415547 @default.
- W1988698678 hasRelatedWork W2470746280 @default.
- W1988698678 hasRelatedWork W2562601531 @default.
- W1988698678 hasRelatedWork W2581813867 @default.
- W1988698678 hasRelatedWork W2872416579 @default.
- W1988698678 hasRelatedWork W2920746509 @default.
- W1988698678 hasRelatedWork W937191531 @default.
- W1988698678 hasVolume "72" @default.
- W1988698678 isParatext "false" @default.
- W1988698678 isRetracted "false" @default.
- W1988698678 magId "1988698678" @default.
- W1988698678 workType "article" @default.