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• W1988704611 abstract "Population diversification strategies are ubiquitous among microbes, encompassing random phase-variation (RPV) of pathogenic bacteria, viral latency as observed in some bacteriophage and HIV, and the non-genetic diversity of bacterial stress responses. Precise conditions under which these diversification strategies confer an advantage have not been well defined. We develop a model of population growth conditioned on dynamical environmental and cellular states. Transitions among cellular states, in turn, may be biased by possibly noisy readings of the environment from cellular sensors. For various types of environmental dynamics and cellular sensor capability, we apply game-theoretic analysis to derive the evolutionarily stable strategy (ESS) for an organism and determine when that strategy is diversification. We find that: (1) RPV, effecting a sort of Parrondo paradox wherein random alternations between losing strategies produce a winning strategy, is selected when transitions between different selective environments cannot be sensed, (2) optimal RPV cell switching rates are a function of environmental lifecycle asymmetries and environmental autocorrelation, (3) probabilistic diversification upon entering a new environment is selected when sensors can detect environmental transitions but have poor precision in identifying new environments, and (4) in the presence of excess additive noise, low-pass filtering is required for evolutionary stability. We show that even when RPV is not the ESS, it may minimize growth rate variance and the risk of extinction due to 'unlucky' environmental dynamics." @default.
• W1988704611 created "2016-06-24" @default.
• W1988704611 creator A5005988887 @default.
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• W1988704611 date "2005-05-01" @default.
• W1988704611 modified "2023-10-18" @default.
• W1988704611 title "Diversity in times of adversity: probabilistic strategies in microbial survival games" @default.
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• W1988704611 doi "https://doi.org/10.1016/j.jtbi.2004.11.020" @default.
• W1988704611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15757681" @default.
• W1988704611 hasPublicationYear "2005" @default.
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