FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988715598> ?p ?o ?g. }

• W1988715598 endingPage "1452" @default.
• W1988715598 startingPage "1442" @default.
• W1988715598 abstract "Bone marrow contains distinct microenvironments that regulate hematopoietic stem cells (HSCs). The endosteal HSC niche includes osteoblasts, mineral, and extracellular matrix proteins that interact through various molecular signals to control HSCs. Sonic hedgehog (Shh) is a morphogen involved in the regulation of skeletal development and hematopoiesis, but the effects of Shh on bone in relation to the HSC niche are not well understood. We demonstrate that systemic overexpression of Shh in mice increases osteoblast number with the resultant formation of new trabeculae in the femoral diaphysis. Suggestive of a functional change in the hematopoietic niche, numbers of Lin(-) Sca-1(+) c-Kit(+) cells with hematopoietic progenitor function expand, although cells with in vivo repopulating capacity in the wild-type environment do not increase. Instead, Shh mediates a decrease in number of bone marrow lymphocytes accompanied by a decreased expression of stromal-derived growth factor 1 (SDF-1) and a decrease in Flk2-expressing Lin(-) Sca-1(+) c-Kit(+) cells, indicating a modulation of early lymphopoiesis. This is caused by a microenvironment-induced mechanism as Shh treatment of bone marrow recipients, but not donors, results in a dramatic depletion of lymphocytes. Together, these data suggest that Shh mediates alterations in the bone marrow hematopoietic niche affecting the early lymphoid differentiation." @default.
• W1988715598 created "2016-06-24" @default.
• W1988715598 creator A5004072401 @default.
• W1988715598 creator A5004804093 @default.
• W1988715598 creator A5016728677 @default.
• W1988715598 creator A5027155026 @default.
• W1988715598 creator A5064433832 @default.
• W1988715598 creator A5074714826 @default.
• W1988715598 creator A5084238530 @default.
• W1988715598 date "2009-08-01" @default.
• W1988715598 modified "2023-10-18" @default.
• W1988715598 title "Sonic Hedgehog Expands Diaphyseal Trabecular Bone Altering Bone Marrow Niche and Lymphocyte Compartment" @default.
• W1988715598 cites W1541949755 @default.
• W1988715598 cites W1545947682 @default.
• W1988715598 cites W1596473475 @default.
• W1988715598 cites W1965107300 @default.
• W1988715598 cites W1969008892 @default.
• W1988715598 cites W1971833736 @default.
• W1988715598 cites W1972127223 @default.
• W1988715598 cites W1973035870 @default.
• W1988715598 cites W1975025595 @default.
• W1988715598 cites W1975217943 @default.
• W1988715598 cites W1975247371 @default.
• W1988715598 cites W1976073214 @default.
• W1988715598 cites W1976550012 @default.
• W1988715598 cites W1978598034 @default.
• W1988715598 cites W1979061689 @default.
• W1988715598 cites W1980401440 @default.
• W1988715598 cites W1982111644 @default.
• W1988715598 cites W1982467518 @default.
• W1988715598 cites W1983668232 @default.
• W1988715598 cites W1983712327 @default.
• W1988715598 cites W1985753831 @default.
• W1988715598 cites W2006859618 @default.
• W1988715598 cites W2011174877 @default.
• W1988715598 cites W2017907565 @default.
• W1988715598 cites W2021103771 @default.
• W1988715598 cites W2021276131 @default.
• W1988715598 cites W2029259805 @default.
• W1988715598 cites W2033414562 @default.
• W1988715598 cites W2036795046 @default.
• W1988715598 cites W2039748263 @default.
• W1988715598 cites W2043474049 @default.
• W1988715598 cites W2053307967 @default.
• W1988715598 cites W2059614045 @default.
• W1988715598 cites W2060146693 @default.
• W1988715598 cites W2060610551 @default.
• W1988715598 cites W2062945727 @default.
• W1988715598 cites W2070793750 @default.
• W1988715598 cites W2077559627 @default.
• W1988715598 cites W2088022688 @default.
• W1988715598 cites W2093818708 @default.
• W1988715598 cites W2095050488 @default.
• W1988715598 cites W2095244767 @default.
• W1988715598 cites W2100378064 @default.
• W1988715598 cites W2116059256 @default.
• W1988715598 cites W2116666381 @default.
• W1988715598 cites W2117602643 @default.
• W1988715598 cites W2120372000 @default.
• W1988715598 cites W2131301194 @default.
• W1988715598 cites W2145319582 @default.
• W1988715598 cites W2150902176 @default.
• W1988715598 doi "https://doi.org/10.1038/mt.2009.102" @default.
• W1988715598 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2835226" @default.
• W1988715598 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19436267" @default.
• W1988715598 hasPublicationYear "2009" @default.
• W1988715598 type Work @default.
• W1988715598 sameAs 1988715598 @default.
• W1988715598 citedByCount "11" @default.
• W1988715598 countsByYear W19887155982012 @default.
• W1988715598 countsByYear W19887155982013 @default.
• W1988715598 countsByYear W19887155982014 @default.
• W1988715598 countsByYear W19887155982018 @default.
• W1988715598 countsByYear W19887155982019 @default.
• W1988715598 countsByYear W19887155982020 @default.
• W1988715598 countsByYear W19887155982022 @default.
• W1988715598 crossrefType "journal-article" @default.
• W1988715598 hasAuthorship W1988715598A5004072401 @default.
• W1988715598 hasAuthorship W1988715598A5004804093 @default.
• W1988715598 hasAuthorship W1988715598A5016728677 @default.
• W1988715598 hasAuthorship W1988715598A5027155026 @default.
• W1988715598 hasAuthorship W1988715598A5064433832 @default.
• W1988715598 hasAuthorship W1988715598A5074714826 @default.
• W1988715598 hasAuthorship W1988715598A5084238530 @default.
• W1988715598 hasBestOaLocation W19887155981 @default.
• W1988715598 hasConcept C109159458 @default.
• W1988715598 hasConcept C16930146 @default.
• W1988715598 hasConcept C201750760 @default.
• W1988715598 hasConcept C202751555 @default.
• W1988715598 hasConcept C203014093 @default.
• W1988715598 hasConcept C2776637008 @default.
• W1988715598 hasConcept C2778086970 @default.
• W1988715598 hasConcept C2778260815 @default.
• W1988715598 hasConcept C2780007613 @default.
• W1988715598 hasConcept C28328180 @default.
• W1988715598 hasConcept C502942594 @default.
• W1988715598 hasConcept C55493867 @default.
• W1988715598 hasConcept C62478195 @default.

• next