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• W1988723183 endingPage "265" @default.
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• W1988723183 abstract "Context: Vinegar has long been used as a condiment and a traditional medicine worldwide.Objective: The current study investigates the antioxidant effect of three types of fruit vinegars (FV) namely pomegranate [Punica granatum L. (Punicaceae)], prickly pear [Opuntia ficus-indica (L.) Mill. (Cactaceae)], and apple [Malus domestica Borkh. (Rosaceae)] vinegars in high-fat diet (HFD)-induced hyperlipidemic Wistar rats.Materials and methods: Fifty male Wistar rats were divided into five groups; HFD (80 cal/d) fed rats were orally dosed with fruit vinegars (7 ml/kg) once daily for 28 weeks. At the end of the experiment, lipid profile, lipid peroxidation products, antioxidant enzymes, and trace elements were assessed in serum. In addition, a liver histopathological study was performed.Results: HFD showed a significant increase (p ≤ 0.05) in lipid profile and TBARS levels when compared with normal control. Daily oral administration of FV normalized various biochemical, metabolic, and histopathological changes. However, pomegranate vinegar exhibited a very significant (p ≤ 0.001) reduction in lipid profile levels (total cholesterol: 165%, triglycerides: 68%, LDL-c: 76%, and atherogenic index: 80%), whereas an increase in antioxidant status (SOD: 7-fold, GPx: 4.81-fold, GRx: 1.66-fold, and TAS: 3.45-fold) when compared with hyperlipidemic control. Histopathological examinations also confirmed the protective effects of pomegranate vinegar against lipid accumulation and the improvement of hepatic lesions.Discussion and conclusion: The fruit vinegars regulate lipid metabolism and decrease liver damage in high-fat fed rats as shown in this study." @default.
• W1988723183 created "2016-06-24" @default.
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• W1988723183 date "2015-04-08" @default.
• W1988723183 modified "2023-09-27" @default.
• W1988723183 title "Effect of fruit vinegars on liver damage and oxidative stress in high-fat-fed rats" @default.
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• W1988723183 doi "https://doi.org/10.3109/13880209.2015.1031910" @default.
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