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- W1988723216 abstract "<h3>Objective.</h3> —To determine risk factors for bloodstream infections (BSIs) in an outbreak among patients receiving home intravenous infusion therapy. <h3>Desing.</h3> —Case-control and retrospective cohort studies. <h3>Setting.</h3> —Home health agency. <h3>Patients.</h3> —Patients receiving home intravenous infusion therapy from Rhode Island Home Therapeutics (RIHT) from January through December 1993. <h3>Main Outcome Measure.</h3> —Development of primary BSI. <h3>Methods.</h3> —We compared patients with BSI (ie, case patients) with randomly selected noninfected RIHT patients receiving intravenous therapy, conducted a cohort study of all RIHT patients receiving intravenous therapy via a central venous catheter (CVC), and conducted a culture survey of injection cap luminal fluid. <h3>Results.</h3> —Case patients were more likely than controls to have had therapy via a CVC (11/11 vs 14/32; odds ratio [OR] undefined;<i>P</i><.001) or total parenteral nutrition and intralipid therapy (TPN/IL) (9/11 vs 3/32; OR, 43.5; 95% confidence interval [CI], 4.9 to 510.0). Among RIHT patients with CVCs, risk factors for BSI were receipt of TPN/IL (9/35 vs 2/67; rate ratio [RR], 8.6; 95% CI, 2.0 to 37.7) or use of a needleless infusion system (10/41 vs 1/61; RR, 14.9; 95% CI, 2.0 to 111.8). Only the combination of both exposures was significantly associated with development of a BSI (<i>P</i><.001). Luminal fluid from injection caps of needleless devices was significantly more likely to be culture positive than fluid from protected-needle devices (5/23 vs 0/18; RR undefined;<i>P</i>=.04). <h3>Conclusions.</h3> —Our data suggest that a needleless device used for TPN/IL was associated with increased risk of BSI when injection caps were changed every 7 days. (<i>JAMA</i>. 1995;273:1862-1864)" @default.
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- W1988723216 date "1995-06-21" @default.
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- W1988723216 title "Bloodstream Infections Associated With a Needleless Intravenous Infusion System in Patients Receiving Home Infusion Therapy" @default.
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- W1988723216 doi "https://doi.org/10.1001/jama.1995.03520470070034" @default.
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