FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988724881> ?p ?o ?g. }

• W1988724881 endingPage "635" @default.
• W1988724881 startingPage "627" @default.
• W1988724881 abstract "The characteristics of [¹²⁵I]Bolton-Hunter[Sar⁹,Met(O₂)¹¹]substance P ([¹²⁵I]BH-SarSP) binding were investigated in membranes of human ascending, transverse, distal, and sigmoid colon circular muscle. Binding of [¹²⁵I]BH-SarSP was of high affinity (<i>K</i>_D = 68 nM) and low capacity (<i>B</i>_max = 0.31 fmol/mg of wet weight tissue), and showed no regional differences. [¹²⁵I]BH-SarSP binding was inhibited by SP ≈ [Pro⁹]SP ≥ (2<i>S</i>,3<i>S</i>)-3-(2-methoxybenzylamino)-2-phenylpiperidine (CP99994) ≫ neurokinin (NK) A ≥ neuropeptide γ > [Lys⁵,MeLeu⁹,Nle¹⁰]-NKA(4–10) ≈ (<i>S</i>)-<i>N</i>-methyl-<i>N</i>[4-acetylamino-4-phenylpiperidino)-2-(3,4-dichlorophenyl) butyl]benzamide (SR48968) ≫ senktide, suggesting binding to NK-1 sites. Most agonists seemed to bind to two sites. In autoradiographic studies, dense binding for [¹²⁵I]BH-SarSP was associated with submucosal and longitudinal muscle blood vessels, and the submucosal margin of circular muscle (corresponding to interstitial cells of Cajal), with moderate binding over most of the circular muscle. In normal colon circular muscle strips, [Pro⁹]SP was almost ineffective, and SP caused contractions with pD₂ values of 5.3 to 5.7. No regional differences were observed in potency or efficacy. Responses to SP were inhibited by the NK-2 receptor antagonist SR48968, but not by NK-1 antagonist CP99994, indicating the involvement of NK-2 rather than NK-1 receptors. Atropine significantly inhibited contractions induced by SP, indicating a minor cholinergic component. Contractile responses to SP were considerably reduced in preparations from patients with diverticular disease, and marginally reduced in ulcerative colitis compared with control. This study clearly demonstrates an NK-1 binding site on human colon circular muscle, but its role in this tissue remains unclear and may not involve contractile mechanisms. The attenuated contractility in specimens with diverticular disease may reflect disease-related alterations of the tachykinin receptor system." @default.
• W1988724881 created "2016-06-24" @default.
• W1988724881 creator A5003412422 @default.
• W1988724881 creator A5012896004 @default.
• W1988724881 creator A5049264813 @default.
• W1988724881 creator A5090693366 @default.
• W1988724881 date "2002-08-01" @default.
• W1988724881 modified "2023-10-17" @default.
• W1988724881 title "Roles of Substance P Receptors in Human Colon Circular Muscle: Alterations in Diverticular Disease" @default.
• W1988724881 cites W179700553 @default.
• W1988724881 cites W1942890471 @default.
• W1988724881 cites W1967620034 @default.
• W1988724881 cites W1972312867 @default.
• W1988724881 cites W1977786504 @default.
• W1988724881 cites W1979562004 @default.
• W1988724881 cites W1980951772 @default.
• W1988724881 cites W1981662665 @default.
• W1988724881 cites W1983991937 @default.
• W1988724881 cites W1985580976 @default.
• W1988724881 cites W1986621119 @default.
• W1988724881 cites W1993031866 @default.
• W1988724881 cites W2001768751 @default.
• W1988724881 cites W2002078683 @default.
• W1988724881 cites W2020256228 @default.
• W1988724881 cites W2032343216 @default.
• W1988724881 cites W2037256203 @default.
• W1988724881 cites W2039029601 @default.
• W1988724881 cites W2039551230 @default.
• W1988724881 cites W2041170896 @default.
• W1988724881 cites W2041881856 @default.
• W1988724881 cites W2049055989 @default.
• W1988724881 cites W2057481258 @default.
• W1988724881 cites W2061623121 @default.
• W1988724881 cites W2076838713 @default.
• W1988724881 cites W2087242764 @default.
• W1988724881 cites W2132987876 @default.
• W1988724881 cites W2140072895 @default.
• W1988724881 cites W2170198360 @default.
• W1988724881 cites W4247936073 @default.
• W1988724881 doi "https://doi.org/10.1124/jpet.102.034702" @default.
• W1988724881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12130725" @default.
• W1988724881 hasPublicationYear "2002" @default.
• W1988724881 type Work @default.
• W1988724881 sameAs 1988724881 @default.
• W1988724881 citedByCount "45" @default.
• W1988724881 countsByYear W19887248812012 @default.
• W1988724881 countsByYear W19887248812013 @default.
• W1988724881 countsByYear W19887248812014 @default.
• W1988724881 countsByYear W19887248812015 @default.
• W1988724881 countsByYear W19887248812016 @default.
• W1988724881 countsByYear W19887248812019 @default.
• W1988724881 countsByYear W19887248812020 @default.
• W1988724881 countsByYear W19887248812021 @default.
• W1988724881 countsByYear W19887248812022 @default.
• W1988724881 countsByYear W19887248812023 @default.
• W1988724881 crossrefType "journal-article" @default.
• W1988724881 hasAuthorship W1988724881A5003412422 @default.
• W1988724881 hasAuthorship W1988724881A5012896004 @default.
• W1988724881 hasAuthorship W1988724881A5049264813 @default.
• W1988724881 hasAuthorship W1988724881A5090693366 @default.
• W1988724881 hasConcept C126322002 @default.
• W1988724881 hasConcept C134018914 @default.
• W1988724881 hasConcept C170493617 @default.
• W1988724881 hasConcept C185592680 @default.
• W1988724881 hasConcept C2991787047 @default.
• W1988724881 hasConcept C2992686903 @default.
• W1988724881 hasConcept C55493867 @default.
• W1988724881 hasConcept C71240020 @default.
• W1988724881 hasConcept C71924100 @default.
• W1988724881 hasConcept C86803240 @default.
• W1988724881 hasConceptScore W1988724881C126322002 @default.
• W1988724881 hasConceptScore W1988724881C134018914 @default.
• W1988724881 hasConceptScore W1988724881C170493617 @default.
• W1988724881 hasConceptScore W1988724881C185592680 @default.
• W1988724881 hasConceptScore W1988724881C2991787047 @default.
• W1988724881 hasConceptScore W1988724881C2992686903 @default.
• W1988724881 hasConceptScore W1988724881C55493867 @default.
• W1988724881 hasConceptScore W1988724881C71240020 @default.
• W1988724881 hasConceptScore W1988724881C71924100 @default.
• W1988724881 hasConceptScore W1988724881C86803240 @default.
• W1988724881 hasIssue "2" @default.
• W1988724881 hasLocation W19887248811 @default.
• W1988724881 hasLocation W19887248812 @default.
• W1988724881 hasOpenAccess W1988724881 @default.
• W1988724881 hasPrimaryLocation W19887248811 @default.
• W1988724881 hasRelatedWork W1996846474 @default.
• W1988724881 hasRelatedWork W2018368842 @default.
• W1988724881 hasRelatedWork W2033472167 @default.
• W1988724881 hasRelatedWork W2034583712 @default.
• W1988724881 hasRelatedWork W2052453588 @default.
• W1988724881 hasRelatedWork W2061429094 @default.
• W1988724881 hasRelatedWork W2063619316 @default.
• W1988724881 hasRelatedWork W2126532023 @default.
• W1988724881 hasRelatedWork W2169225653 @default.
• W1988724881 hasRelatedWork W2414846389 @default.
• W1988724881 hasVolume "302" @default.
• W1988724881 isParatext "false" @default.
• W1988724881 isRetracted "false" @default.

• next