FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988736741> ?p ?o ?g. }

• W1988736741 endingPage "S16" @default.
• W1988736741 startingPage "S16" @default.
• W1988736741 abstract "We report an analysis of a protein network of functionally linked proteins, identified from a phylogenetic statistical analysis of complete eukaryotic genomes. Phylogenetic methods identify pairs of proteins that co-evolve on a phylogenetic tree, and have been shown to have a high probability of correctly identifying known functional links. The eukaryotic correlated evolution network we derive displays the familiar power law scaling of connectivity. We introduce the use of explicit phylogenetic methods to reconstruct the ancestral presence or absence of proteins at the interior nodes of a phylogeny of eukaryote species. We find that the connectivity distribution of proteins at the point they arise on the tree and join the network follows a power law, as does the connectivity distribution of proteins at the time they are lost from the network. Proteins resident in the network acquire connections over time, but we find no evidence that 'preferential attachment' – the phenomenon of newly acquired connections in the network being more likely to be made to proteins with large numbers of connections – influences the network structure. We derive a 'variable rate of attachment' model in which proteins vary in their propensity to form network interactions independently of how many connections they have or of the total number of connections in the network, and show how this model can produce apparent power-law scaling without preferential attachment. A few simple rules can explain the topological structure and evolutionary changes to protein-interaction networks: most change is concentrated in satellite proteins of low connectivity and small phenotypic effect, and proteins differ in their propensity to form attachments. Given these rules of assembly, power law scaled networks naturally emerge from simple principles of selection, yielding protein interaction networks that retain a high-degree of robustness on short time scales and evolvability on longer evolutionary time scales." @default.
• W1988736741 created "2016-06-24" @default.
• W1988736741 creator A5041084357 @default.
• W1988736741 creator A5053582890 @default.
• W1988736741 creator A5082054411 @default.
• W1988736741 date "2007-01-01" @default.
• W1988736741 modified "2023-09-23" @default.
• W1988736741 title "Assembly rules for protein networks derived from phylogenetic-statistical analysis of whole genomes" @default.
• W1988736741 cites W1490286156 @default.
• W1988736741 cites W1623155147 @default.
• W1988736741 cites W1996207277 @default.
• W1988736741 cites W2008620264 @default.
• W1988736741 cites W2024120506 @default.
• W1988736741 cites W2029158589 @default.
• W1988736741 cites W2030159301 @default.
• W1988736741 cites W2042220296 @default.
• W1988736741 cites W2065304353 @default.
• W1988736741 cites W2101546326 @default.
• W1988736741 cites W2102225814 @default.
• W1988736741 cites W2112768399 @default.
• W1988736741 cites W2114525641 @default.
• W1988736741 cites W2116088151 @default.
• W1988736741 cites W2117526623 @default.
• W1988736741 cites W2137786672 @default.
• W1988736741 cites W2140827816 @default.
• W1988736741 cites W2142437744 @default.
• W1988736741 cites W2142510328 @default.
• W1988736741 cites W3103071483 @default.
• W1988736741 cites W3103786587 @default.
• W1988736741 cites W4236956086 @default.
• W1988736741 cites W4252706339 @default.
• W1988736741 cites W4254712992 @default.
• W1988736741 doi "https://doi.org/10.1186/1471-2148-7-s1-s16" @default.
• W1988736741 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1796610" @default.
• W1988736741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17288574" @default.
• W1988736741 hasPublicationYear "2007" @default.
• W1988736741 type Work @default.
• W1988736741 sameAs 1988736741 @default.
• W1988736741 citedByCount "16" @default.
• W1988736741 countsByYear W19887367412012 @default.
• W1988736741 countsByYear W19887367412013 @default.
• W1988736741 countsByYear W19887367412022 @default.
• W1988736741 crossrefType "journal-article" @default.
• W1988736741 hasAuthorship W1988736741A5041084357 @default.
• W1988736741 hasAuthorship W1988736741A5053582890 @default.
• W1988736741 hasAuthorship W1988736741A5082054411 @default.
• W1988736741 hasBestOaLocation W19887367411 @default.
• W1988736741 hasConcept C104317684 @default.
• W1988736741 hasConcept C113174947 @default.
• W1988736741 hasConcept C114614502 @default.
• W1988736741 hasConcept C121332964 @default.
• W1988736741 hasConcept C136764020 @default.
• W1988736741 hasConcept C141231307 @default.
• W1988736741 hasConcept C193252679 @default.
• W1988736741 hasConcept C26619641 @default.
• W1988736741 hasConcept C2779413310 @default.
• W1988736741 hasConcept C2780600066 @default.
• W1988736741 hasConcept C32946077 @default.
• W1988736741 hasConcept C33923547 @default.
• W1988736741 hasConcept C34947359 @default.
• W1988736741 hasConcept C41008148 @default.
• W1988736741 hasConcept C54355233 @default.
• W1988736741 hasConcept C62520636 @default.
• W1988736741 hasConcept C70721500 @default.
• W1988736741 hasConcept C78458016 @default.
• W1988736741 hasConcept C86803240 @default.
• W1988736741 hasConcept C90132467 @default.
• W1988736741 hasConceptScore W1988736741C104317684 @default.
• W1988736741 hasConceptScore W1988736741C113174947 @default.
• W1988736741 hasConceptScore W1988736741C114614502 @default.
• W1988736741 hasConceptScore W1988736741C121332964 @default.
• W1988736741 hasConceptScore W1988736741C136764020 @default.
• W1988736741 hasConceptScore W1988736741C141231307 @default.
• W1988736741 hasConceptScore W1988736741C193252679 @default.
• W1988736741 hasConceptScore W1988736741C26619641 @default.
• W1988736741 hasConceptScore W1988736741C2779413310 @default.
• W1988736741 hasConceptScore W1988736741C2780600066 @default.
• W1988736741 hasConceptScore W1988736741C32946077 @default.
• W1988736741 hasConceptScore W1988736741C33923547 @default.
• W1988736741 hasConceptScore W1988736741C34947359 @default.
• W1988736741 hasConceptScore W1988736741C41008148 @default.
• W1988736741 hasConceptScore W1988736741C54355233 @default.
• W1988736741 hasConceptScore W1988736741C62520636 @default.
• W1988736741 hasConceptScore W1988736741C70721500 @default.
• W1988736741 hasConceptScore W1988736741C78458016 @default.
• W1988736741 hasConceptScore W1988736741C86803240 @default.
• W1988736741 hasConceptScore W1988736741C90132467 @default.
• W1988736741 hasIssue "Suppl 1" @default.
• W1988736741 hasLocation W19887367411 @default.
• W1988736741 hasLocation W19887367412 @default.
• W1988736741 hasLocation W19887367413 @default.
• W1988736741 hasLocation W19887367414 @default.
• W1988736741 hasOpenAccess W1988736741 @default.
• W1988736741 hasPrimaryLocation W19887367411 @default.
• W1988736741 hasRelatedWork W1988736741 @default.
• W1988736741 hasRelatedWork W2093925352 @default.
• W1988736741 hasRelatedWork W2130436157 @default.
• W1988736741 hasRelatedWork W2151003257 @default.

• next