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- W1988740124 abstract "Biology presents us with an array of design principles. From studies of both simple and more complex systems, we understand some of the fundamentals of how nature works and what goes wrong in the disease state. We are interested in using the foundations of biology to engineer cells in a logical and predictable way to perform certain functions with relevance to therapeutics and diagnostics. By necessity, the predictable engineering of biology requires knowledge of quantitative behavior of individual cells and communities and the ability to construct reliable models. By building and analyzing synthetic systems, we learn more about the fundamentals of biological design as well as engineer useful living devices with myriad applications. For example, we are interested in building cells that can perform specific tasks, such as remembering past events and thus acting as a biological computer. In particular, we have built genetic circuits whereby cells can ‘remember’ stimuli for many generations including DNA damage and hypoxia. By characterizing these ‘memory’ cells, we can identify key genes that may act as therapeutic targets and explanations for persistence of a subset of cells in tumors. Citation Format: Pamela A. Silver. Designing biological systems to report on disease [abstract]. In: Proceedings of the AACR Special Conference on Chemical Systems Biology: Assembling and Interrogating Computational Models of the Cancer Cell by Chemical Perturbations; 2012 Jun 27-30; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2012;72(13 Suppl):Abstract nr IA4." @default.
- W1988740124 created "2016-06-24" @default.
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- W1988740124 date "2012-07-01" @default.
- W1988740124 modified "2023-09-25" @default.
- W1988740124 title "Abstract IA4: Designing biological systems to report on disease" @default.
- W1988740124 doi "https://doi.org/10.1158/1538-7445.csb12-ia4" @default.
- W1988740124 hasPublicationYear "2012" @default.
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