Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988746232> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1988746232 endingPage "410" @default.
- W1988746232 startingPage "397" @default.
- W1988746232 abstract "We have isolated a Chinese hamster ovary cell mutant (DMPR-2) simultaneously resistant to diphtheria toxin and modeccin. In addition to the increased resistance to these two toxins used in the selection, this mutant is more resistant to Pseudomonas toxin and hypersensitive to ricin than the parental cell line. In contrast to the wild-type cells in which nigericin protects cells from modeccin, the cytotoxicity of modeccin in the DMPR-2 mutant is enhanced by nigericin. We have also studied the effects of nigericin and NH4Cl on the cytotoxicity of modeccin in a modeccin-resistant mutant of HeLa cells (ModRI). The cytotoxicity of modeccin is enhanced by nigericin in ModRI mutant cells, in contrast to the protection of modeccin cytotoxicity by nigericin in the parental HeLa cells. Our results suggest that modeccin can reach the cytosol of mammalian cells by two distinct routes; the major route requires endosomal acidification and the minor route is activated by nigericin." @default.
- W1988746232 created "2016-06-24" @default.
- W1988746232 creator A5071347000 @default.
- W1988746232 creator A5086906851 @default.
- W1988746232 date "1988-02-01" @default.
- W1988746232 modified "2023-10-16" @default.
- W1988746232 title "Enhancement of cytotoxicity of modeccin by nigericin in modeccin-resistant mutant cell lines" @default.
- W1988746232 cites W1487851602 @default.
- W1988746232 cites W1488021123 @default.
- W1988746232 cites W1498549327 @default.
- W1988746232 cites W169781986 @default.
- W1988746232 cites W1893651774 @default.
- W1988746232 cites W1973201384 @default.
- W1988746232 cites W1987095504 @default.
- W1988746232 cites W1999595885 @default.
- W1988746232 cites W2005375212 @default.
- W1988746232 cites W2017894518 @default.
- W1988746232 cites W2051868743 @default.
- W1988746232 cites W2096490954 @default.
- W1988746232 cites W2124541465 @default.
- W1988746232 cites W2126277284 @default.
- W1988746232 cites W2137333901 @default.
- W1988746232 cites W2161432922 @default.
- W1988746232 cites W2214628785 @default.
- W1988746232 cites W4243161998 @default.
- W1988746232 cites W4247478626 @default.
- W1988746232 cites W4254420249 @default.
- W1988746232 doi "https://doi.org/10.1016/0014-4827(88)90310-2" @default.
- W1988746232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3338496" @default.
- W1988746232 hasPublicationYear "1988" @default.
- W1988746232 type Work @default.
- W1988746232 sameAs 1988746232 @default.
- W1988746232 citedByCount "15" @default.
- W1988746232 crossrefType "journal-article" @default.
- W1988746232 hasAuthorship W1988746232A5071347000 @default.
- W1988746232 hasAuthorship W1988746232A5086906851 @default.
- W1988746232 hasConcept C104317684 @default.
- W1988746232 hasConcept C109316439 @default.
- W1988746232 hasConcept C143065580 @default.
- W1988746232 hasConcept C153911025 @default.
- W1988746232 hasConcept C175656101 @default.
- W1988746232 hasConcept C202751555 @default.
- W1988746232 hasConcept C2777330628 @default.
- W1988746232 hasConcept C2777366897 @default.
- W1988746232 hasConcept C2777367657 @default.
- W1988746232 hasConcept C33057221 @default.
- W1988746232 hasConcept C41625074 @default.
- W1988746232 hasConcept C54355233 @default.
- W1988746232 hasConcept C55493867 @default.
- W1988746232 hasConcept C81885089 @default.
- W1988746232 hasConcept C86803240 @default.
- W1988746232 hasConcept C95444343 @default.
- W1988746232 hasConceptScore W1988746232C104317684 @default.
- W1988746232 hasConceptScore W1988746232C109316439 @default.
- W1988746232 hasConceptScore W1988746232C143065580 @default.
- W1988746232 hasConceptScore W1988746232C153911025 @default.
- W1988746232 hasConceptScore W1988746232C175656101 @default.
- W1988746232 hasConceptScore W1988746232C202751555 @default.
- W1988746232 hasConceptScore W1988746232C2777330628 @default.
- W1988746232 hasConceptScore W1988746232C2777366897 @default.
- W1988746232 hasConceptScore W1988746232C2777367657 @default.
- W1988746232 hasConceptScore W1988746232C33057221 @default.
- W1988746232 hasConceptScore W1988746232C41625074 @default.
- W1988746232 hasConceptScore W1988746232C54355233 @default.
- W1988746232 hasConceptScore W1988746232C55493867 @default.
- W1988746232 hasConceptScore W1988746232C81885089 @default.
- W1988746232 hasConceptScore W1988746232C86803240 @default.
- W1988746232 hasConceptScore W1988746232C95444343 @default.
- W1988746232 hasIssue "2" @default.
- W1988746232 hasLocation W19887462321 @default.
- W1988746232 hasLocation W19887462322 @default.
- W1988746232 hasOpenAccess W1988746232 @default.
- W1988746232 hasPrimaryLocation W19887462321 @default.
- W1988746232 hasRelatedWork W1515193666 @default.
- W1988746232 hasRelatedWork W1601301841 @default.
- W1988746232 hasRelatedWork W1979034442 @default.
- W1988746232 hasRelatedWork W1988746232 @default.
- W1988746232 hasRelatedWork W1990076587 @default.
- W1988746232 hasRelatedWork W2059515698 @default.
- W1988746232 hasRelatedWork W2059756718 @default.
- W1988746232 hasRelatedWork W2164503313 @default.
- W1988746232 hasRelatedWork W2391637057 @default.
- W1988746232 hasRelatedWork W4254420249 @default.
- W1988746232 hasVolume "174" @default.
- W1988746232 isParatext "false" @default.
- W1988746232 isRetracted "false" @default.
- W1988746232 magId "1988746232" @default.
- W1988746232 workType "article" @default.